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Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes

Current Osteoporosis Reports, 2020
Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state-based on hyperglycemia and accumulation of advanced glycation end products among other ...
Arancha R. Gortázar, Juan A. Ardura
openaire   +2 more sources

The osteocyte: a multifunctional cell within the bone.

Annals of Anatomy, 2019
The knowledge of bone biology has largely changed in the last few decades. Osteocytes are multifunctional bone cells that are surrounded by mineralized bone matrix and for decades it was considered that they might be relatively inactive cells.
F. Tresguerres   +5 more
semanticscholar   +1 more source

Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice.

Bone, 2020
Moderate exercise can alleviate symptoms of osteoarthritis (OA) such as pain, stiffness, and joint deformities that are associated with progressive cartilaginous degeneration, osteophyte formation, subchondral bone changes, and synovial inflammation ...
Zihao He   +11 more
semanticscholar   +1 more source

The osteocyte lineage

Archives of Biochemistry and Biophysics, 2008
The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
openaire   +2 more sources

Isolation of fossil osteocytes

Journal of the Royal Microscopical Society, 1965
During routine maceration of shales for the extraction of fossil spores, a number of unusual structures appeared which were eventually identified as osteocytes from scales belonging to a palaeoniscid, a primitive bony fish. No vertebrate tissues had been expected, since the technique employed destroys virtually all substances with the exception of ...
R, NEVES, L B, TARLO
openaire   +2 more sources

Osteocyte and bone structure

Current Osteoporosis Reports, 2003
The osteocyte is the most abundant cell type of bone. There are approximately 10 times as many osteocytes as osteoblasts in adult human bone, and the number of osteoclasts is only a fraction of the number of osteoblasts. Our current knowledge of the role of osteocytes in bone metabolism is far behind our insight into the properties and functions of the
Klein Nulend, J.   +2 more
openaire   +3 more sources

In Vivo Osteocyte Death

The Journal of Bone & Joint Surgery, 1960
Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age.
openaire   +2 more sources

Skeletal infections: microbial pathogenesis, immunity and clinical management

Nature Reviews Microbiology, 2022
Elysia A Masters   +2 more
exaly  

Osteocyte

2021
Jasmine Akbarzadeh, Cristina Godoy
openaire   +1 more source

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