Results 101 to 110 of about 143,725 (292)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Growth characteristics in individuals with osteogenesis imperfecta in North America: results from a multicenter study. [PDF]

, 2019
PurposeOsteogenesis imperfecta (OI) predisposes people to recurrent fractures, bone deformities, and short stature. There is a lack of large-scale systematic studies that have investigated growth parameters in OI.MethodsUsing data from the Linked ...
A Lund, A Markmann, AD Letocha, AK Anissipour, Allison Tam, B Sykes, BJ Belt-Niedbala, Brendan Lee, BU Nwosu, C Land, D Gatti, David Cuthbertson, DO Sillence, DR Keene, EL Germain-Lee, ER Barros, F Rauch, F Rauch, FH Glorieux, Francis H. Glorieux, Frank Rauch, I Grafe, Jay R. Shapiro, JC Marini, JC Marini, JD Hald, Jeff Krischer, JM Tanner, K Graff, L Zeitlin, LA Dimeglio, Mahim Jain, Mary Mullins, Melanie Pepin, MG Seikaly, Michael B. Bober, Michaela Durigova, MS Aglan, N Bishop, N Bishop, Peter A. Smith, Peter H. Byers, R Sakkers, RH Engelbert, RH Engelbert, RM Patel, Robert D. Steiner, RT Hamza, S Bellur, Sandesh C. S. Nagamani, Sunil Bellur, T Palomo, T Yang, Tracy Hart, U Vetter, V. Reid Sutton, Y Takeuchi   +56 more
core   +2 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Osteogenesis Imperfecta [PDF]

Autopsy and Case Reports, 2018
Bruno Kusznir Vitturi, Amanda Frias, Fabiana Toledo Bueno Pereira, José Donato de Próspero, Caroline Queren Fernandes, Geanete Pozzan   +5 more
openaire   +3 more sources

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

FasL induces expression of Mmp13 and Osterix in bone cells

Bone Reports, 2021
Adéla Kratochvílová, Barbora Veselá, Eva Švandová, Reinhard Gruber, Eva Matalová   +4 more
doaj   +1 more source

Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α2β1 Signaling. [PDF]

, 2016
Unlabelled: The induction of mesenchymal stem cells (MSCs) toward the osteoblastic lineage using osteogenic supplements prior to implantation is one approach under examination to enhance their bone-forming potential.
Harvestine, Jenna N, Hoch, Allison I, Leach, J Kent, Murphy, Kaitlin C, Zhou, Dejie   +4 more
core   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Endothelial cell-derived exosomes trigger a positive feedback loop in osteogenesis-angiogenesis coupling via up-regulating zinc finger and BTB domain containing 16 in bone marrow mesenchymal stem cell

Journal of Nanobiotechnology
The close spatial and temporal connection between osteogenesis and angiogenesis around type H vasculature is referred as “osteogenesis-angiogenesis coupling”, which is one of the basic mechanisms of osteogenesis.
Lu Liu, Nan Zhou, Songning Fu, Linlin Wang, Yadong Liu, Changfeng Fu, Feng Xu, Weiying Guo, Yanhua Wu, Jin Cheng, Jun Dai, Yipeng Wang, Xiaofeng Wang, Qiwei Yang, Yuanyi Wang   +14 more
doaj   +1 more source

Adipose-derived stem cells: a review of osteogenesis differentiation [PDF]

, 2016
Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects.
Mazurek, Urszula, Sikora, Bartosz, Skubis, Aleksandra, Wojdas, Emilia, Zmarzły, Nikola   +4 more
core   +2 more sources