Results 81 to 90 of about 165,191 (338)

The IMPACT survey: a mixed methods study to understand the experience of children, adolescents and adults with osteogenesis imperfecta and their caregivers

Orphanet Journal of Rare Diseases
Background Osteogenesis imperfecta (OI) is a rare, heritable connective tissue disorder associated with a variety of symptoms, that affect individuals’ quality of life (QoL) and can be associated with increased healthcare resource use. While some aspects
Ingunn Westerheim, Tracy Hart, Taco van Welzenis, Lena Lande Wekre, Oliver Semler, Cathleen Raggio, Michael B. Bober, Maria Rapoport, Samantha Prince, Frank Rauch   +9 more
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

A Patient With Severe Maxillary Gingival Exposure Treated With Combined Compression Osteogenesis of the Anterior Alveolar Bone and Conventional Le Fort I Osteotomy [PDF]

, 2013
Excessive gingival exposure at the maxillary anterior region during not only smiling (a gummy face) but also at rest creates both functional and aesthetic problems for patients. We herein introduce a unique treatment procedure for mandibular retrognathia
Kohara, Haruka, Asahina, Izumi, Yoshida, Noriaki, Kawasaki, Takako, Fujimura, Yuji, Ohba, Seigo   +5 more
core   +1 more source

The IMPACT Survey: the economic impact of osteogenesis imperfecta in adults

Orphanet Journal of Rare Diseases
Background The IMPACT survey aimed to elucidate the humanistic, clinical and economic burden of osteogenesis imperfecta (OI) on individuals with OI, their families, caregivers and wider society.
Tracy Hart, Ingunn Westerheim, Taco van Welzenis, Oliver Semler, Cathleen Raggio, Frank Rauch, Ruby Dadzie, Samantha Prince, Lena Lande Wekre   +8 more
doaj   +1 more source

BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis

Frontiers in Cell and Developmental Biology, 2020
Angiogenesis and osteogenesis are tightly coupled during bone modeling and remodeling processes. Here we reported that bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-29a promotes angiogenesis and osteogenesis in vitro and in vivo.
Guo-Dong Lu, Peng Cheng, Ting Liu, Zhong Wang   +3 more
semanticscholar   +1 more source

EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling

Stem cell research & therapeutics, 2021
Background Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined.
Jun-Jie Shen, Yi Sun, Xuan-Zhe Liu, Yu Zhu, Bing-Bo Bao, Tao Gao, Y. Chai, Jia Xu, Xian-You Zheng   +8 more
semanticscholar   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Stapes surgery in osteogenesis imperfecta: retrospective analysis of 34 operated ears. [PDF]

, 2011
Item does not contain fulltextIntraoperative findings of stapes surgery in 34 ears from 22 patients with genetically confirmed osteogenesis imperfecta (OI) are reported, as well as the audiometric results after the longest postoperative follow-up ...
Swinnen, Freya, Swinnen, FreyaUZGent002001436766802000236573977914973664F9644220-F0ED-11E1-A9DE-61C894A0A6B4, De Leenheer, Els, Swinnen, F.K.R., Coucke, PaulGE31UZGent0001712314708010016360240000-0001-7119-586XF6730D80-F0ED-11E1-A9DE-61C894A0A6B4, Leenheer, E.M. De, Cremers, Cor, Coucke, Paul, Cremers, Cor WRJ, Dhooge, IngeborgGE34UZGent8010008783130000-0002-5915-1079F4A8B1EE-F0ED-11E1-A9DE-61C894A0A6B4, Cremers, C.W.R.J., Coucke, P.J., Dhooge, I.J., Dhooge, Ingeborg, De Leenheer, ElsGE34UZGent8020000108470000-0002-2789-3529F841462C-F0ED-11E1-A9DE-61C894A0A6B4   +14 more
core   +1 more source

The IMPACT Survey: the humanistic impact of osteogenesis imperfecta in adults

BMC Public Health
Background The IMPACT Survey explored the humanistic, clinical, and economic burden of osteogenesis imperfecta (OI) on individuals with OI, their families, caregivers, and wider society.
Taco van Welzenis, Ingunn Westerheim, Tracy Hart, Lena Lande Wekre, Oliver Semler, Frank Rauch, Laetitia Dewavrin, Ruby Dadzie, Samantha Prince, Cathleen Raggio   +9 more
doaj   +1 more source

PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regeneration

Stem Cell Research & Therapy, 2021
Background Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs that over-express specific cytokines, growth factors, or chemokines have shown great promise in ...
Ning Zhang, Chi-Wen Lo, Takeshi Utsunomiya, Masahiro Maruyama, Ejun Huang, Claire Rhee, Qi Gao, Zhenyu Yao, Stuart B. Goodman   +8 more
doaj   +1 more source