Results 121 to 130 of about 145,083 (306)

Avulsion fracture of the olecranon for the diagnosis of osteogenesis imperfecta case report

Acta Orthopaedica et Traumatologica Turcica, 2021
Avulsion fractures of olecranon in children are very rare and often associated with osteogenesis imperfecta. In this study we report a child who has been followed for constitutional growth retardation for five years.
Abdurrahman Ozcelik, Akin Turgut, Gokhan Maralcan, Sinan Seber   +3 more
doaj  

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network

, 2006
Several homeodomain (HD) proteins are critical for skeletal patterning and respond directly to BMP2 as an early step in bone formation. RUNX2, the earliest transcription factor proven essential for commitment to osteoblastogenesis, is also expressed in ...
Aberg, Acampora, Afzal, Amjad Javed, Andre J. van Wijnen, Aronow, Bae, Balint, Banerjee, Banerjee, Beanan, Bendall, Bryan, Cheng, Choi, Depew, Depew, Drissi, Drissi, Ducy, Ferrari, Fujita, Gary S. Stein, Gaur, Ghoul-Mazgar, Harris, Hassan, Hoffmann, Ichida, Ishii, Jane B. Lian, Janet L. Stein, Kim, Komori, Lallemand, Lee, Lengner, Lengner, Lundberg, Maria I. Morasso, Matthew Mandeville, McKeown, Miyama, Mohammad Q. Hassan, Nakashima, Newberry, Otto, Owen, Park, Pratap, Provot, Rahul S. Tare, Robinson, Robledo, Roca, Rosen, Ryoo, Satokata, Satokata, Semba, Shirakabe, Smith, Stricker, Suk Hee Lee, Ten Dijke, Vaes, van Gurp, Xu, Yoshizawa, Zaidi, Zaidi, Zambotti   +71 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions

Journal of Dental Sciences
Background/purpose: Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation.
Hui-Min Wang, Qian Ding, Ying Chen, Yao-Jun Zhang, Zhi-Xiao Wu, Xiao Zhang, Lei Zhang   +6 more
doaj   +1 more source

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing

Advanced Science, EarlyView.
A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman, Cong Truc Huynh, Marcus J. Goudie, Peyton J. Tebon, Hyojin Ko, Minh Khanh Nguyen, Kaelyn L. Gasvoda, Yang Song, Kirsten Fetah, Ali Khademhosseini, Song Li, Eben Alsberg   +11 more
wiley   +1 more source

Osteogenesis Imperfecta [PDF]

Archives of Disease in Childhood, 1956
J G, DAVEL, T, FICHARDT, D, VAN DER SPUY
openaire   +2 more sources

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1

Biological Research
Background Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous scars, impede osteogenesis remains ...
Fei Huang, Guozhen Wei, Hai Wang, Ying Zhang, Wenbin Lan, Yun Xie, Gui Wu   +6 more
doaj   +1 more source