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Osteoinduction, osteoconduction and osseointegration [PDF]
European Spine Journal, 2001 Osteoinduction is the process by which osteogenesis is induced. It is a phenomenon regularly seen in any type of bone healing process. Osteoinduction implies the recruitment of immature cells and the stimulation of these cells to develop into preosteoblasts.
Johansson C, Carina Johansson
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Journal of Dental Research, 2012
Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with osteoinductive potential have emerged. Over the last 50 years, however, our ability to describe biological phenomena accurately has been improved dramatically by advancements in cell and molecular biology. The aim of this review is to divide the osteoinduction
Yufeng Zhang
exaly +3 more sources
Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with osteoinductive potential have emerged. Over the last 50 years, however, our ability to describe biological phenomena accurately has been improved dramatically by advancements in cell and molecular biology. The aim of this review is to divide the osteoinduction
Yufeng Zhang
exaly +3 more sources
Archives of orthopaedic and traumatic surgery, 1982
Using a previously described experimental model for demonstration of osteoinduction biological activity of variably prepared fractions of demineralized bone matrix was studied. Sequential extraction of matrix using CaCl2, EDTA, LiCl and water results in an acceleration of the induction process and a reduction of immunological host reaction in the case ...
F W, Thielemann +2 more
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Using a previously described experimental model for demonstration of osteoinduction biological activity of variably prepared fractions of demineralized bone matrix was studied. Sequential extraction of matrix using CaCl2, EDTA, LiCl and water results in an acceleration of the induction process and a reduction of immunological host reaction in the case ...
F W, Thielemann +2 more
openaire +2 more sources
Osteoinduction by biomaterials—Physicochemical and structural influences
Journal of Biomedical Materials Research - Part A, 2006AbstractOsteoinduction by biomaterials has been shown to be a real phenomenon by many investigators in the last decade. The exact mechanism of this phenomenon is, however, still largely unknown. This in vivo study in goats was performed to get insight into processes governing the phenomenon of osteoinduction by biomaterials and had four main goals: (i)
Pamela Habibović +2 more
exaly +4 more sources
Gene Therapy for Osteoinduction
Current Gene Therapy, 2004Various disorders of bone and mineral metabolism are diagnosed to be defective in genes related to cellular growth and differentiation. Gene therapy to introduce normal copy of defective genes into cells and tissues to compensate for silent, minimally expressed or mutated genes can be accomplished by multiple approaches.
Sanjay, Kumar, Selvarangan, Ponnazhagan
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GENE THERAPY FOR OSTEOINDUCTION
Orthopedic Clinics of North America, 1999One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future.
A A, Scaduto, J R, Lieberman
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Intramembranous bone matrix is osteoinductive
The Anatomical Record, 1994AbstractAll known bone‐derived osteoinductive factors have been isolated from endochondral (EC) bones and all initiate bone induction via EC ossification. However, to date no attempt has been made to isolate comparable factors from bones which form initially and completely via intramembranous (IM) ossification.
C K, Scott, S D, Bain, J A, Hightower
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Rapid quantitative bioassay of osteoinduction
Journal of Orthopaedic Research, 2000AbstractWe developed a reproducible, relatively rapid bioassay that quantitatively correlates with the osteoinductive capacity of demineralized bone matrix obtained from human long bones. We have found that Saos human osteosarcoma cells proliferate in response to incubation with demineralized bone matrix and that an index of this proliferative activity
H D, Adkisson +5 more
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