Results 51 to 60 of about 118,831 (311)

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

E.coli Associated Extensive Bilateral Maxillary Osteomyelitis: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2013
With the advent of broad spectrum antibiotics, chronic osteomyelitis of jaw, especially of maxilla, has become a rare lesion. Osteomyelitis of jaw is associated with a complex microbiota, the most common oral microorganism being, Staphylococcus sp ...
Subrat Kumar Padhiary, Gunjan Srivastava, Swagatika Panda, Santosh Subudhi, Sthitaprajna Lenka   +4 more
doaj   +1 more source

Reconstruction of Nonunion Tibial Fractures in War-Wounded Iraqi Civilians, 2006-2008: Better Late Than Never [PDF]

, 2012
OBJECTIV
Al Ani, A M K, Alras, M S, Baron, E, Daumas, L, Fakri, R M, Hérard, P, Khaddaj, S, Rose, A M C   +7 more
core   +2 more sources

Chronic Osteomyelitis

Current Infectious Disease Reports, 2012
Chronic osteomyelitis is a multifaceted bacterial infection with common features. It absolutely requires surgery for remission. The duration and form of concomitant administration of antibiotic agents for adult patients is still based on expert opinion.
Uckay, Ilker, Jugun, Kheeldass, Gamulin, Axel Dorian G., Wagener, Joe, Hoffmeyer, Pierre, Lew, Daniel Pablo   +5 more
openaire   +5 more sources

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Osteomyelitis in Deep Sternal Wound Infections: Revisited—A Single-Center Observational Study

Life
Objective: Sternum osteomyelitis and deep sternal wound infection (DSWI) are often used to describe the same clinical condition interchangeably. The aim of our current study is to investigate the prevalence of osteomyelitis in cardiac surgery patients ...
Stephan Raab, Tina Schaller, Evaldas Girdauskas, Sebastian Reindl   +3 more
doaj   +1 more source

Acute exacerbation of chronic osteomyelitis triggered by aggravation of type 2 diabetes mellitus: a case report

Journal of Medical Case Reports, 2019
Background Osteomyelitis is an infection in a bone. Acute osteomyelitis is observed mainly in the long leg bones of children and is usually treated with antibiotics.
Shintaro Irie, Takatoshi Anno, Fumiko Kawasaki, Ryo Shigemoto, Hideaki Kaneto, Kohei Kaku, Niro Okimoto   +6 more
doaj   +1 more source

Real-World Use of Oritavancin for the Treatment of Osteomyelitis

Drugs - Real World Outcomes, 2020
Osteomyelitis is a difficult-to-treat disease that can require both surgical debridement and a prolonged course of antimicrobial therapy. Current standard of care for the antimicrobial treatment of osteomyelitis is fraught with multiple challenges and ...
Patrick J. Scoble, Joseph Reilly, Glenn S. Tillotson   +2 more
doaj   +1 more source

Factors affecting the outcome of lower extremity osteomyelitis treated with microvascular free flaps: an analysis of 65 patients

Journal of Orthopaedic Surgery and Research, 2021
Background Free flaps have been a useful modality in the management of lower extremity osteomyelitis particularly in limb salvage. This study aimed to determine the factors affecting the outcome of free flap reconstruction in the treatment of ...
Duy Quang Thai, Yeon Kyo Jung, Hyung Min Hahn, Il Jae Lee   +3 more
doaj   +1 more source

Osteoblastoma of the femur in a patient with recurrent paronychia : case report [PDF]

, 2009
Background: Osteoblastoma is a rare primary benign bone tumor that has varied radiologic presentation depending on the affected site. In selected cases, differential diagnosis with subacute osteomyelitis is necessary. Case Report: The authors present the
Babiak, Ireneusz, Gołębiowski, Marek, Palczewski, Piotr, Wiśniewska, Małgorzata, Świątkowski, Jan   +4 more
core