Results 71 to 80 of about 48,007 (294)

Low Oxygen Tension Enhances Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells with Osteonecrosis-Related Functional Impairment

Stem Cells International, 2015
Objective. Glucocorticoids can affect the function of bone marrow-derived mesenchymal stem cells (BMMSCs) adversely and merit the requirement for a strategy to correct this anomaly; we assessed the effect of low oxygen (2%) on BMMSCs from rabbits with ...
Lihong Fan, Ruiyu Liu, Jia Li, Zhibin Shi, Xiaoqian Dang, Kunzheng Wang   +5 more
doaj   +1 more source

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

, 2016
Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis.
Xiangjun Cai (780959), Leonard A. Mattano Jr. (3181083), Laura J Janke, Kelli L. Boyd (245348), Jitesh D Kawedia, Laura B Ramsey, Kelli L Boyd, Xiangjun Cai, Mary V. Relling (47096), Amy J. Funk (3181086), Leonard A Mattano, Chengcheng Liu, Amy J Funk, Mary V Relling, Jitesh D. Kawedia (384551), Chengcheng Liu (402506), Laura J. Janke (780957), Laura B. Ramsey (780956)   +17 more
core   +1 more source

Safety profile comparison of intra‐articular corticosteroids, hyaluronic acid, platelet‐rich plasma, and cell‐based injections for knee osteoarthritis: A systematic review and meta‐analysis by the ESSKA Orthobiologics Initiative

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The aim was to compare the safety profiles of corticosteroids (CS), hyaluronic acid (HA), blood‐derived products based on platelet concentrates (for simplicity indicated as PRP ‐ platelet‐rich plasma ‐ being PRP the most common product), and cell‐based therapies (namely products exploiting the therapeutic function of mesenchymal ...
Alessandro Bensa, Andrea Piano, Giacomo Arthur Fumagalli, Laura de Girolamo, Lior Laver, Jérémy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo   +8 more
wiley   +1 more source

Collagen‐membrane‐covered matrix‐associated chondrocyte implantation improves safety over periosteum‐covered MACI for large knee cartilage defects: A real‐world data analysis in the registry study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This registry study aimed to evaluate the safety and effectiveness of collagen membrane‐covered matrix‐associated autologous chondrocyte implantation (cMACI) versus periosteum‐covered MACI (pMACI) for large knee cartilage defects (Outerbridge III–IV, ≥4 cm²) in the femorotibial and/or patellofemoral joints with a minimum 2‐year follow ...
Yuji Uchio, Ryosuke Kuroda, Yasuo Niki, Katsura Sugawara, Yasuyuki Ishibash   +4 more
wiley   +1 more source

Factors associated with dislocation after total hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head: a multicenter cohort study of 5,983 hips

Acta Orthopaedica
Background and purpose: Nontraumatic osteonecrosis of the femoral head (ONFH) patients are at a higher dislocation risk after primary total hip arthroplasties (THAs) than osteoarthrosis patients.
Seneki Kobayashi, Nobuhiko Sugano, Wataru Ando, Wakaba Fukushima, Kyoko Kondo, Takashi Sakai   +5 more
doaj   +1 more source

Magnetic resonance imaging‐based axial‐plane analysis of lower extremity torsion with dedicated 3D planning software is reliable and efficient

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The reliability and efficiency of a dedicated 3D planning software were evaluated for magnetic resonance imaging (MRI)‐based measurement of femoral torsion, tibial torsion, knee version and whole‐lower extremity torsion compared with manual assessment.
Johanna Lippuner, Felix Hüttner, Felix Ferner, Dorothée Sinha, Veronika Weyer‐Elberich, Björn Vogt, Mauricio Kfuri, Mirco Herbort, Jörg Harrer   +8 more
wiley   +1 more source

Clinical Experience With Eliglustat in Children With Gaucher Disease Type 1

American Journal of Medical Genetics Part A, EarlyView.
Erika R. Vucko, Allegra Quadri, Rachel E. Hickey, Carly A. Rasmussen, Monika Izdebski, Joel Charrow, Carlos E. Prada   +6 more
wiley   +1 more source

Specific functional knee phenotypes are associated with increased osteoarthritis progression: A ≥10‐year longitudinal study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate osteoarthritis (OA) progression across functional knee phenotypes (FKPs) over a follow‐up period of ≥10 years. Methods This retrospective longitudinal study included 388 patients (764 knees) with healthy knees or early OA (Kellgren–Lawrence grade ≤1) at baseline and a minimum follow‐up of 10 years.
Sang Jun Song, Hyo Beom Lee, Cheol Hee Park   +2 more
wiley   +1 more source

Analysis of m6A regulators related immune characteristics in ankylosing spondylitis by integrated bioinformatics and computational strategies

Scientific Reports
N6-methyladenosine (m6A) modification, as a common epigenetic modification, has been widely studied in autoimmune diseases. However, the role of m6A in the regulation of the immune microenvironment of ankylosing spondylitis (AS) remains unclear ...
Da Guo, Jiayi Liu, Shuang Li, Peng Xu
doaj   +1 more source

Hip arthroplasty for treatment of advanced osteonecrosis: comprehensive review of implant options, outcomes and complications

, 2016
Warit Waewsawangwong, Pirapat Ruchiwit, James I Huddleston, Stuart B Goodman Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA Abstract: Surgical treatment for late stage (post-collapse) osteonecrosis of the femoral head is ...
Ruchiwit P, Goodman SB, Huddleston JI, Waewsawangwong W   +3 more
core