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Exploring the pathogenesis of steroid-induced osteonecrosis of the femoral head co-regulated by mesenchymal stem cells and pyroptosis-related genes with the use of transcriptome. [PDF]

Eur J Med Res
Rong XB, Wang WW, Ding Q, Tian Z, Guo L, Tao HC, Niu CC, Mo XS, Liu JF, Zeng P.   +9 more
europepmc   +1 more source

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Osteonecrosis of the Femoral Head

Hip Surgery, 2020
Osteonecrosis of the femoral head (ONFH) is a refractory disease caused by the disruption or impairment of blood supply to the femoral head. It is followed by the death of osteocytes and bone marrow as well as subsequent bone repair, which in turn leads to the structural changes and collapse of the femoral head, and joint dysfunction. Since Munro first
Changqing Zhang, D. Jin, J. Sheng, Weitao Jia, J. Guan, Sen Lin, Zhenzhong Zhu, Hao Wu, Youshui Gao   +8 more
semanticscholar   +4 more sources

Osteonecrosis of the femoral head.

Journal of the American Academy of Orthopaedic Surgeons, 1999
New cases of osteonecrosis of the femoral head in the United States number between 10,000 and 20,000 per year. This disease usually affects patients in their late 30s and early 40s. Although a number of authors have related specific risk factors to this disease, its etiology, pathogenesis, and treatment remain a source of considerable controversy. This
C. Lavernia, R. J. Sierra, F. Grieco
semanticscholar   +5 more sources

Osteonecrosis of the Femoral Head

Journal of the American Academy of Orthopaedic Surgeons, 2014
Osteonecrosis of the femoral head may lead to progressive destruction of the hip joint. Although the etiology of osteonecrosis has not been definitely delineated, risk factors include corticosteroid use, alcohol consumption, trauma, and coagulation abnormalities.
P. Gallinaro, A. Massè, Angiola Valente, Claudio Cuocolo   +3 more
semanticscholar   +4 more sources

Osteonecrosis of the Femoral Head

, 2017
Management of osteonecrosis of the femoral head is dependent on the stage of the disease and if there is collapse of the femoral head. Nonoperative management is rarely indicated, whereas core decompression with grafting can be a successful treatment method if used prior to collapse of the femoral head. For cases where subchondral collapse has occurred,
W. Pannell, J. Lieberman
semanticscholar   +3 more sources

Resveratrol prevents steroid‐induced osteonecrosis of the femoral head via miR‐146a modulation

Annals of the New York Academy of Sciences, 2021
The purpose of this study was to investigate the possible use of resveratrol (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and to explore the detailed mechanisms.
Kai Nan, Jun-peng Pei, L. Fan, Yuan-kai Zhang, Xin Zhang, Kang Liu, Zhi-bin Shi, Xiao-qian Dang, Kun-zheng Wang   +8 more
semanticscholar   +1 more source

Clinical Performance and Outcomes of an Injectable Bone Graft Substitute Following Core Decompression during the Treatment of Osteonecrosis of the Femoral Head

The Journal of Hip Surgery, 2022
Osteonecrosis of the femoral head (ONFH) can be challenging to manage, as it primarily affects younger adult patients. Hip preservation is preferred in this population, and there is a heightened focus on treatment strategies such as biologic adjuvants ...
Kara McConaghy, Erika Louiselle, Ashley D Knight, P. Rullán, R. A. Hortensius, D. Fitch, N. Piuzzi   +6 more
semanticscholar   +1 more source