Results 31 to 40 of about 184,982,520 (176)

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

BMC Musculoskeletal Disorders, 2020
Background Long-term use of steroid may lead to osteonecrosis of the femoral head (ONFH). Mechanical stress may help bone formation and remodeling. This study aimed to probe the role of mechanical stress in the femoral head recovery in rats.
Dapeng Fu, Kairong Qin, Sheng Yang, Jianmin Lu, Haoyi Lian, Dewei Zhao   +5 more
doaj   +1 more source

Spontaneous femoral neck fracture resulting from osteonecrosis involving lateral femoral head-neck junction: a retrospective study

BMC Musculoskeletal Disorders, 2023
Background Spontaneous femoral neck fracture is a rare condition that remains controversial due to limited reported cases. This retrospective study aims to provide further insights into the etiology and characteristics of the disease. Method We conducted
Xin Guo, Yihui Zeng, Haijun Xu, Xinyuan Zhan   +3 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Osteonecrosis of the femoral head [PDF]

, 1999
New cases of osteonecrosis of the femoral head in the ...
MD Rafael J Sierra, MD Francisco R Grieco, MD J J Lavernia, Md, MD Carlos J Lavernia   +4 more
core  

Osteonecrosis of the Femoral Head

, 2017
Comprised exclusively of clinical cases involving osteonecrosis of the femoral head (ONFH), this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly diagnose and treat both pre- and post-collapse ...
Sierra, Rafael J.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service), Sierra, Rafael J., D'Apuzzo, Michele   +3 more
core   +2 more sources

Hip Arthroscopy in Adults Aged 40 or Older Produces Clinically Meaningful Symptom Improvement but Carries a Substantial Risk of Conversion to Total Hip Arthroplasty: A Systematic Review

Arthroscopy, EarlyView.
Purpose To report conversion rates to total hip arthroplasty (THA), patient‐reported outcome measures, and complication rates in adults aged ≥ 40 years undergoing hip arthroscopy since 2016. Methods MEDLINE, EMBASE, and PubMed were searched from January 2016 to March 2025, and pertinent data were abstracted from eligible studies according to the ...
Helena Son, Benjamin Blackman, Joshua Dworsky‐Fried, Dan Cohen, Yoan Bourgeault‐Gagnon, Axel Öhlin, Nicole Simunovic, Iqbal Multani, Tyler M. Hauer, Craig S. Mauro, Olufemi Ayeni   +10 more
wiley   +1 more source

Atraumatic osteonecrosis of the humeral head: pathophysiology and current concepts of evaluation and treatment

JSES Reviews, Reports, and Techniques, 2022
The humeral head is considered the second most common site for osteonecrosis to occur after the femoral head. As seen in the femoral head, the circulatory implications characteristic of this condition are attributable to the interaction between a genetic
Juan Sebastián Castillo Mercado, MD, Jorge Rojas Lievano, MD, MSc, Brandon Zaldivar, MD, Camilo Barajas, MD, Guido Fierro, MD, Juan Carlos González, MD, MSc   +5 more
doaj   +1 more source

Low expression of vascular endothelial growth factor and high serum level of cyclic guanine monophosphate as the risk factors of femoral head osteonecrosis in alcohol-exposed Wistar rat

Chinese Journal of Traumatology, 2020
Purpose: Severe damage to the femoral head in patients with osteonecrosis has a high impact on morbidity. Despite early diagnosis, the treatment outcome is still unsatisfactory.
I Ketut Suyasa, Anak Agung Wiradewi Lestari   +1 more
doaj   +1 more source