Results 51 to 60 of about 40,701 (228)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis

Metabolites
Introduction: This study aimed to capture the early metabolic changes before osteoporosis occurs and identify metabolomic biomarkers at the osteopenia stage for the early prevention of osteoporosis.
Jie Wang, Dandan Yan, Suna Wang, Aihua Zhao, Xuhong Hou, Xiaojiao Zheng, Jingyi Guo, Li Shen, Yuqian Bao, Wei Jia, Xiangtian Yu, Cheng Hu, Zhenlin Zhang   +12 more
doaj   +1 more source

A Possible Case of Temporomandibular Joint Dislocation, Trepanation, and Metabolic Bone Disease in a Young Adolescent From North‐Central Myanmar (1000–700 bce)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT This osteobiography explores the life history of an adolescent who lived during the early‐mid Bronze Age (c. 1000–700 bce) and was buried at Nyaung'gan, a site in north‐central Myanmar. Burial 3b had multiple skeletal lesions, and their bones were covered in well‐remodeled subperiosteal new bone.
Anna Willis, Baptiste Pradier, Thu Thu Win, T. O. Pryce   +3 more
wiley   +1 more source

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Clinical impact of low bone mineral density in patients with colorectal cancer liver metastasis undergoing hepatectomy.

PLoS ONE
BackgroundThis study aimed to elucidate the clinical impact of osteopenia on the recurrence of colon cancer liver metastases.MethodsPatients with colon cancer liver metastases (N = 186) undergoing hepatectomy at Jichi Medical University Hospital between ...
Yuichi Aoki, Atsushi Miki, Yasunaru Sakuma, Jun Watanabe, Takehiro Kagaya, Makiko Tahara, Takumi Teratani, Kazuhiro Endo, Hideki Sasanuma, Wataru Nishimura, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Hironori Yamaguchi   +13 more
doaj   +1 more source

Sarcopenia, Bone Mineral Density, and Vitamin D: Epifloripa Aging Study 2013/2014 [PDF]

Geriatrics, Gerontology and Aging
OBJECTIVE: To verify associations between osteopenia/osteoporosis and vitamin D and sarcopenia in the older adult population of Florianópolis, Brazil. METHODS: A cross-sectional population-based study, with 604 older adults (60 years and over).
Susana Cararo Confortin, Lariane Mortean Ono, Larissa Pruner Marques, Thamara Hubler Figueiró, Gilciane Ceolin, Aline Rodrigues Barbosa, Eleonora d'Orsi   +6 more
doaj   +1 more source

Reducing unnecessary osteoporosis treatment in prostate cancer with FRAX‐BMD integration

UroPrecision, EarlyView.
ABSTRACT Background Men on androgen deprivation therapy (ADT) for prostate cancer frequently develop osteoporosis, and up to 20% fracture within five years. The Fracture Risk Assessment Tool (FRAX) estimates 10‐year fracture probability with or without bone mineral density (BMD), but data in this population are scarce.
Takashi Kawahara, Masanobu Yamazaki, Akihito Hashizume, Daiki Ueno, Yasuhide Miyoshi, Koichi Uemura, Yusuke Ito, Hiroki Ito, Kazuhide Makiyama, Jun‐ichi Teranishi, Hiroji Uemura   +10 more
wiley   +1 more source

Marked Subchondral Bandlike Osteopenia on Radiography after Trauma and Inactivity: A Report of four Cases

Case Reports in Orthopedics, 2013
We report about four cases of marked subchondral osteopenia on followup radiography after trauma and prolonged disuse. This localized form of disuse osteopenia has not been reported in details beside the followup imaging of talar neck fractures, where it
J. Gossner, B. W. Raab, J. Larsen, S. Breitkreuz   +3 more
doaj   +1 more source

Prevalence of osteoporosis and osteopenia in advanced chronic obstructive pulmonary disease patients

Lung India, 2011
Background: Reduction of bone mineral density (BMD) is a known and established phenomenon in chronic obstructive pulmonary disease (COPD). However, there have been no data regarding osteoporosis/osteopenia in COPD patients in India.
Parthasarathi Bhattacharyya, Rantu Paul, Malabika Ghosh, Ratna Dey, Rana Dey, Nirjoo Barooah, Saidul Islam, Dipabali Acharya, Saikat Nag, Sujan Bardhan   +9 more
doaj   +1 more source