Results 101 to 110 of about 75,213 (253)

Porcine bone scaffolds adsorb growth factors secreted by MSCs and improve bone tissue repair [PDF]

, 2017
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo . To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan
Bressan, Eriberto, Ferroni, Letizia, Gardin, Chiara, Mijiritsky, Eitan, Piattelli, Adriano, Zanette, Gastone, Zavan, Barbara   +6 more
core   +2 more sources

Osteopontin is a therapeutic target that drives breast cancer recurrence

Nature Communications
Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes.
Yu Gu, Tarek Taifour, Tung Bui, Dongmei Zuo, Alain Pacis, Alexandre Poirier, Sherif Attalla, Anne-Marie Fortier, Virginie Sanguin-Gendreau, Tien-Chi Pan, Vasilios Papavasiliou, Nancy U. Lin, Melissa E. Hughes, Kalie Smith, Morag Park, Michel L. Tremblay, Lewis A. Chodosh, Rinath Jeselsohn, William J. Muller   +18 more
doaj   +1 more source

Role of Remodelling in Adolescent Idiopathic Scoliosis: an Evaluation of Osteopontin Level [PDF]

, 2012
Introduction.Though many clinicians who deal with spinal deformity do understand the meaning of idiopathic scoliosis, answer regarding its cause remains an enigma. Better understanding concerning its etiopathology should improve clinicians' ability
Gatam, L. (Luthfi), Hoo, C. (Charles)
core  

Osteopontin expression in reactive lesions of gingiva

Journal of Applied Oral Science, 2015
Reactive proliferations of the gingiva comprise lesions such as pyogenic granuloma (PG), inflammatory fibroepithelial hyperplasia (IFH), peripheral ossifying fibroma (POF), and peripheral giant cell lesion.
Rathinam ELANAGAI, Veeran VEERAVARMAL, Ramdas Madhavan NIRMAL   +2 more
doaj   +1 more source

Head‐to‐head comparison of the diagnostic value of fecal and serum carcinoembryonic antigen for colorectal cancer detection

International Journal of Cancer, EarlyView.
What's New? The diagnostic value of fecal versus serum carcinoembryonic antigen (CEA) for colorectal cancer detection remains unclear. This study provides a head‐to‐head comparison of serum and fecal CEA using matched samples from two large colorectal cancer screening studies and two fecal sample processing methods.
Xianzhe Li, Zitong Zhao, Lara Stassen, Anjana Pradeep Maya, Megha Bhardwaj, Teresa Seum, Janhavi R. Raut, Tafirenyika Gwenzi, Michael Hoffmeister, Petra Schrotz‐King, Hermann Brenner   +10 more
wiley   +1 more source

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Journal of Immunology Research, 2016
Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions
Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti   +11 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Diagnostic value of osteopontin in ovarian cancer: a meta-analysis and systematic review.

PLoS ONE, 2015
AimsOsteopontin (OPN) plays an important role in many physiological and pathological processes (wound healing, inflammation, immune response, and tumorigenesis).
Zhi-De Hu, Ting-Ting Wei, Min Yang, Ning Ma, Qing-Qin Tang, Bao-Dong Qin, Hai-Tao Fu, Ren-Qian Zhong   +7 more
doaj   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source