Results 81 to 90 of about 49,469 (298)

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway

Journal of Translational Medicine, 2012
Background Nasopharyngeal carcinoma (NPC) is well-known for its highly metastatic characteristics, but little is known of its molecular mechanisms. New biomarkers that predict clinical outcome, in particular the ability of the primary tumor to develop ...
Chen Chang-Han, Shiu Li-Yen, Su Li-Jen, Huang Chi-Ying F, Huang Shun-Chen, Huang Chao-Cheng, Yin Yu-Fang, Wang Wei-Sheng, Tsai Hsin-Ting, Fang Fu-Min, Chuang Wan-Chu, Kang Hong-Chang, Hwang Chung-Feng   +12 more
doaj   +1 more source

Az osteopontin gén polimorfizmusa egy román tarka tejelő tehenészetben

, 2014
A kísérlet célja az volt, hogy PCR-RFLP technika segítségével megvizsgáljuk, hogy egy román tarka tejelő tehenészet egyedei hordozzák-e az osteopontin gén polimorfizmusát, és eredményeinket összehasonlítsuk korábbi kísérletek eredményeivel.gjBiológiaBSc ...
Szappanos, Lilla Virág
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Identification of osteopontin in water buffalo semen

, 2007
The competitiveness of buffalo breeding will depend on the utilization of reproductive biotechnologies that allows acceleration of genetic progress. A major factor hampering the efficiency of both artificial insemination and in vitro embryo production ...
LOMBARDI, PIETRO, AVALLONE, LUIGI, Killian G. J., ZICARELLI, LUIGI, PERO, MARIA ELENA, GASPARRINI, BIANCA   +5 more
core   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity

Scientific Reports, 2019
Cytokines play a critical role in the pathogenesis and development of cardiovascular diseases. However, data linking cytokines to risk and severity of acute coronary syndrome (ACS) are still limited.
Kuai Yu, Binyao Yang, Haijing Jiang, Jun Li, Kai Yan, Xuezhen Liu, Lue Zhou, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Xiaoting Luo, Wenhua Mei, Shunchang Sun, Liyun Zhang, Xiang Cheng, Meian He, Xiaomin Zhang, An Pan, Frank B. Hu, Tangchun Wu   +20 more
doaj   +1 more source

Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma

Cholesteatoma is a common disease of the middle ear. Currently, surgical removal is the only treatment option and patients face a high risk of relapse. The molecular basis of cholesteatoma remains largely unknown.
Li Xie (108913), Aiguo Liu (129871), Xiang Lu (158823), Jin Hu (187088), Chao He (466651), Lingling Zeng (519902), Wen Zhou (49050)   +6 more
core   +1 more source

Human Fibroblast‐Myeloid cell tissue atlas across lung, synovium, skin and heart

Arthritis &Rheumatology, Accepted Article.
Background The availability of single‐cell RNA sequencing (scRNAseq data) in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer

BMC Cancer, 2012
Background The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer
Rud Ane, Lund-Iversen Marius, Berge Gisle, Brustugun Odd, Solberg Steinar K, Mælandsmo Gunhild M, Boye Kjetil   +6 more
doaj   +1 more source

Effects of supplemental osteopontin on intestinal development and serum antibody responses to rotavirus vaccination in piglets

, 2011
Milk contains numerous bioactive substances including immunoglobulins, cytokines, growth factors and components that exert antibiotic and prebiotic activity (Field, 2005).
Lu, Jin
core