Results 71 to 80 of about 49,469 (298)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Osteopontin presentation affects cell adhesion-Influence of underlying surface chemistry and nanopatterning of osteopontin

, 2010
Osteopontin is a promising coating material for biomaterials, being important both in remodeling and formation of mineralized tissue and in immunological responses.
Duch, M, Lovmand, J, Esben S. Sørensen, Jenny Malmström, Christensen, B, Sutherland, DS, Malmstrom Pendred, Jenny, Brian Christensen, Jette Lovmand, Mogens Duch, Duncan S. Sutherland, Sorensen, ES   +11 more
core   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

Osteopontin Impairs Host Defense During Pneumococcal Pneumonia

, 2011
Methods. To determine the role of osteopontin in the host response during pneumococcal pneumonia, osteopontin knockout (KO) and normal wild-type (WT) mice were intranasally infected with viable S. pneumoniae. Results.
de Vos, Alex F., Tijmen J. Hommes, Arie J. Hoogendijk, Tom van der Poll, Schouten, Marcel, Alex F. de Vos, Hoogendijk, Arie J., Hommes, Tijmen J., Gerritje J. W. van der Windt, van der Poll, Tom, Florquin, Sandrine, Sandrine Florquin, van der Windt, Gerritje J. W., Marcel Schouten   +13 more
core   +1 more source

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source

Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.

, 2010
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core  

Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men

, 2017
<b><i>Background and Objectives:</i></b> The matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease.
Feldreich, T,, Feldreich, T., Lind, Lars,, Helmersson, Johanna,, Carlsson, A. C., Risérus, Ulf,, Lars Lind, Johanna Helmersson-Karlqvist, Arnlov, J, Larsson, Anders,, Carlsson, AC, Risérus, U., Ärnlöv, Johan,, Anders Larsson, Tobias Feldreich, Axel C. Carlsson, Helmersson-Karlqvist, J., Carlsson, Axel C,, Helmersson-Karlqvist, J, Lind, L, Larsson, A, Feldreich, T, Larsson, A., Ulf Risérus, Riserus, U, Lind, L., Johan Ärnlöv   +26 more
core   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation

Türk Kardiyoloji Derneği Arşivi, 2017
Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality. Atrial fibrosis augments recurrence rate following AF catheter ablation.
Hacı Murat Güneş, Gamze Babur Güler, Ekrem Güler, Gültekin Günhan Demir, Filiz Kızılırmak Yılmaz, Mehmet Onur Omaygenç, Ayşe İstanbullu Tosun, Taylan Akgün, Bilal Boztosun, Fethi Kılıçarslan   +9 more
doaj   +1 more source

The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis

PLOS ONE, 2017
Sarcoidosis is a systemic inflammatory disease of unknown etiology. Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases.To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single ...
Hadas Lavi, Miri Assayag, Assaf Schwartz, Nissim Arish, Zvi G Fridlender, Neville Berkman   +5 more
openaire   +4 more sources