Results 51 to 60 of about 49,469 (298)

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) and galectin‐3hiCD206+ macrophages is ...
Kohsuke Shirakawa, Jin Endo, Masaharu Kataoka, Yoshinori Katsumata, Atsushi Anzai, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Seien Ko, Shinichi Goto, Genki Ichihara, Keiichi Fukuda, Tohru Minamino, Motoaki Sano   +13 more
doaj   +1 more source

Different effects of global osteopontin and macrophage osteopontin in glomerular injury [PDF]

American Journal of Physiology-Renal Physiology, 2018
Osteopontin (OPN) is a pro-and anti-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidneys. To characterize further the role of OPN in kidney injury
Jessica, Trostel, Luan D, Truong, Carlos, Roncal-Jimenez, Makoto, Miyazaki, Shinobu, Miyazaki-Anzai, Masanari, Kuwabara, Rachel, McMahan, Ana, Andres-Hernando, Yuka, Sato, Thomas, Jensen, Miguel A, Lanaspa, Richard J, Johnson, Gabriela E, Garcia   +12 more
openaire   +2 more sources

Estrogen-stimulated endothelial repair requires osteopontin

, 2008
OBJECTIVE: Estradiol (E(2)) is known to accelerate reendothelialization and thus prevent intimal thickening and in-stent restenosis after angioplasty. Transplantation experiments with ERalpha(-/-) mice have previously shown that E(2) acts through local ...
Gadeau, Alain-Pierre, Desgranges, Claude, Filipe, Cédric, Duplàa, Cécile, Lenfant, Françoise, Robbesyn, Fanny, Deutsch, Urban, Leen, Laetitia Lam Shang, Billon, Audrey, Arnal, Jean-François, Garmy-Susini, Barbara, Daret, Danièle, Lam Shang Leen, Laetitia, Jalvy, Sandra, Werner, Nikos, Rittling, Susan R, Allières, Cécile, Nickenig, Georg, Dufourcq, Pascale   +18 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

The Role of Osteopontin and Osteopontin Aptamer (OPN-R3) in Fibroblast Activity [PDF]

Journal of Surgical Research, 2012
Scarring is believed to be caused by both persistent inflammation and overexuberant fibroblast activation. Osteopontin (OPN) is a cytokine that promotes cell activation. The absence of OPN in vivo reduces dermal scarring. This suggests that OPN is involved in scar formation; however, how OPN exerts these pro-scarring effects is unknown.
Cedric, Hunter, Jennifer, Bond, Paul C, Kuo, Maria Angelica, Selim, Howard, Levinson   +4 more
openaire   +2 more sources

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

The effect of osteopontin and osteopontin-derived peptides on preterm brain injury [PDF]

Journal of Neuroinflammation, 2014
Osteopontin (OPN) is a highly phosphorylated sialoprotein and a soluble cytokine that is widely expressed in a variety of tissues, including the brain. OPN and OPN-derived peptides have been suggested to have potential neuroprotective effects against ischemic brain injury, but their role in preterm brain injury is unknown.We used a hypoxia-ischemia (HI)
Albertsson, Anna-Maj, Zhang, Xiaoli, Bi, Dan, Nair, Syam, Qiao, Lili, Hagberg, Henrik, Mallard, Carina, Wang, Xiaoyang, Leavenworth, Jianmei, Cantor, Harvey   +9 more
openaire   +4 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the αXβ2 Integrin [PDF]

The Journal of Immunology, 2009
Abstract Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process ...
Schack, Lotte, Stapulionis, Romualdas, Christensen, Brian, Kofod-Olsen, Emil, Sørensen, Uffe B. Skov, Vorup-Jensen, Thomas; id_orcid 0000-0002-4140-6563, Sørensen, Esben S; id_orcid 0000-0002-7050-3354, Höllsberg, Per   +7 more
openaire   +3 more sources