Results 31 to 40 of about 49,469 (298)
The role of extracellular matrix phosphorylation on energy dissipation in bone
eLife, 2020 Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function.
Stacyann Bailey +9 more
doaj +1 more source
Skeletal Muscle, 2019 Background Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in their expression patterns and effects ...
Dimuthu K. Wasgewatte Wijesinghe +2 more
doaj +1 more source
Osteopontin in Cancer: Mechanisms and Therapeutic Targets
International Journal of Translational Medicine, 2022 Despite significant advances in the understanding of cancer biology, cancer is still a leading cause of death worldwide. Expression of the tumor microenvironment component, osteopontin, in tumor tissues, plasma, and serum, has been shown to be associated
Yoshinobu Kariya, Yukiko Kariya
doaj +1 more source
Circulation Research, 1999 Vascular calcification is widely regarded as merely a rare, end-stage, passive, degenerative, and inevitable process of aging. Decades ago, atherosclerosis had been similarly dismissed, but extensive research finally demonstrated its active regulation. Current research is now revising outdated views of vascular calcification.
L L, Demer, Y, Tintut
openaire +2 more sources
Intraluminal application of vascular endothelial growth factor enhances healing of microvascular anastomosis in a rat model [PDF]
, 2005 Background: Early reconstitution after injury to the endothelium is an important feature for reducing a number of vessel wall pathologies. We investigated the effect of vascular endothelial growth factor ( VEGF) and its impact on the vascular remodeling ...
Hollenberg, S. M. +8 more
core +1 more source
An antibody-free sample pretreatment method for osteopontin combined with MALDI-TOF MS/MS analysis.
PLoS ONE, 2019 Osteopontin is an osteoblast-secreted protein with an aspartic acid-rich, highly phosphorylated, and glycosylated structure. Osteopontin can easily bind to integrins, tumor cells, extracellular matrix and calcium, and is related to bone diseases, various
Yuye Zhou, Joakim Romson, Åsa Emmer
doaj +1 more source
Journal of Pharmacological Sciences, 2005 Osteopontin has been reported to have an important role in cardiac fibrosis. However, little is known about the effects of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin type 1 receptor blockers (ARB) on osteopontin expression in ...
Takanori Kusuyama +10 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Osteopontin Activation and Microcalcification in Venous Grafts Can Be Modulated by Dexamethasone
Cells, 2023 Background: Osteopontin has been implicated in vascular calcification formation and vein graft intimal hyperplasia, and its expression can be triggered by pro-inflammatory activation of cells.
Liam W. McQueen +7 more
doaj +1 more source
, 2018 Previous studies have shown that osteopontin (OPN) can enhance infant resistance to infection. However, the underlying mechanisms remain to be explored.
Xiaoyan Chen (146508) +5 more
core +1 more source