Results 31 to 40 of about 52,783 (282)
The ins and outs of osteopontin [PDF]
OncoImmunology, 2015 The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the
Chiodoni, C. +3 more
openaire +3 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Tumor Biology, 2017 Osteopontin-c splicing isoform activates ovarian cancer progression features. Imbalanced expression of splicing factors from serine/arginine -rich and heterogeneous ribonucleoproteins families has been correlated with the generation of oncogenic splicing
Durval Santos Marques +4 more
doaj +1 more source
TRACP as an Osteopontin Phosphatase [PDF]
Journal of Bone and Mineral Research, 2003 Abstract TRACP is synthesized as a latent proenzyme requiring proteolytic processing to attain maximal phosphatase activity. Excision of an exposed loop domain abolishes the interaction between the loop residue Asp146 and a ligand to the redox-sensitive iron of the active site, most likely Asn91, providing a mechanism for the enzyme ...
Göran, Andersson +7 more
openaire +2 more sources
The role of extracellular matrix phosphorylation on energy dissipation in bone
eLife, 2020 Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function.
Stacyann Bailey +9 more
doaj +1 more source
Skeletal Muscle, 2019 Background Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in their expression patterns and effects ...
Dimuthu K. Wasgewatte Wijesinghe +2 more
doaj +1 more source
Circulation Research, 1999 Vascular calcification is widely regarded as merely a rare, end-stage, passive, degenerative, and inevitable process of aging. Decades ago, atherosclerosis had been similarly dismissed, but extensive research finally demonstrated its active regulation. Current research is now revising outdated views of vascular calcification.
L L, Demer, Y, Tintut
openaire +2 more sources
An antibody-free sample pretreatment method for osteopontin combined with MALDI-TOF MS/MS analysis.
PLoS ONE, 2019 Osteopontin is an osteoblast-secreted protein with an aspartic acid-rich, highly phosphorylated, and glycosylated structure. Osteopontin can easily bind to integrins, tumor cells, extracellular matrix and calcium, and is related to bone diseases, various
Yuye Zhou, Joakim Romson, Åsa Emmer
doaj +1 more source
Osteopontin in Cancer: Mechanisms and Therapeutic Targets
International Journal of Translational Medicine, 2022 Despite significant advances in the understanding of cancer biology, cancer is still a leading cause of death worldwide. Expression of the tumor microenvironment component, osteopontin, in tumor tissues, plasma, and serum, has been shown to be associated
Yoshinobu Kariya, Yukiko Kariya
doaj +1 more source
Neuroprotection by Osteopontin in Stroke [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2005 Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic functions, including inflammation, cell migration, and antiapoptotic processes. Here we investigate the neuroprotective potential of OPN to reduce cell death using both in vitro and in vivo models of ischemia.
Robert, Meller +9 more
openaire +2 more sources