Results 31 to 40 of about 75,213 (253)
Structural studies of hydrated samples of amorphous calcium phosphate and phosphoprotein nanoclusters [PDF]
, 2016 There are abundant examples of nanoclusters and inorganic microcrystals in biology. Their study under physiologically relevant conditions remains challenging due to their heterogeneity, instability, and the requirements of sample preparation.
Holt, Carl +8 more
core +1 more source
Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis [PDF]
, 2018 We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 ...
Anglani F. +8 more
core +1 more source
Skeletal Muscle, 2019 Background Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in their expression patterns and effects ...
Dimuthu K. Wasgewatte Wijesinghe +2 more
doaj +1 more source
The role of extracellular matrix phosphorylation on energy dissipation in bone
eLife, 2020 Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function.
Stacyann Bailey +9 more
doaj +1 more source
Osteopontin in Cancer: Mechanisms and Therapeutic Targets
International Journal of Translational Medicine, 2022 Despite significant advances in the understanding of cancer biology, cancer is still a leading cause of death worldwide. Expression of the tumor microenvironment component, osteopontin, in tumor tissues, plasma, and serum, has been shown to be associated
Yoshinobu Kariya, Yukiko Kariya
doaj +1 more source
Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]
, 2015 PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A +11 more
core +4 more sources
An antibody-free sample pretreatment method for osteopontin combined with MALDI-TOF MS/MS analysis.
PLoS ONE, 2019 Osteopontin is an osteoblast-secreted protein with an aspartic acid-rich, highly phosphorylated, and glycosylated structure. Osteopontin can easily bind to integrins, tumor cells, extracellular matrix and calcium, and is related to bone diseases, various
Yuye Zhou, Joakim Romson, Åsa Emmer
doaj +1 more source
Journal of Pharmacological Sciences, 2005 Osteopontin has been reported to have an important role in cardiac fibrosis. However, little is known about the effects of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin type 1 receptor blockers (ARB) on osteopontin expression in ...
Takanori Kusuyama +10 more
doaj +1 more source
EMBO Molecular Medicine, 2021 Graphical Abstract This study independently confirms increased levels of osteopontin in COVID‐19 patients but also suggests that osteopontin cannot be used as a biomarker of SARS‐CoV‐2 infection, as elevated levels of circulating osteopontin are found in
Giuseppe Cappellano +6 more
doaj +1 more source
Osteopontin Activation and Microcalcification in Venous Grafts Can Be Modulated by Dexamethasone
Cells, 2023 Background: Osteopontin has been implicated in vascular calcification formation and vein graft intimal hyperplasia, and its expression can be triggered by pro-inflammatory activation of cells.
Liam W. McQueen +7 more
doaj +1 more source