Results 21 to 30 of about 54,052 (278)
Brazilian Dental Science, 2022 Objective: Periodontitis is a multifactorial inflammatory disease usually terminated with tooth loss when untreated. Type-2 diabetes mellitus (T2DM) have shown to exacerbate periodontitis.
Ahmed Makki A. Al-Qarakhli +4 more
doaj +1 more source
Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface
Frontiers in Cell and Developmental Biology, 2023 Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines +4 more
doaj +1 more source
Osteopontin in Cardiovascular Diseases [PDF]
Biomolecules, 2021 Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally. These findings suggest the need to reconsider cardiovascular risk and optimal medical therapy.
Kohsuke Shirakawa, Motoaki Sano
openaire +3 more sources
Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]
, 2011 Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg +21 more
core +2 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Osteopontin is an arginine-glycine–aspartate (RGD) containing adhesive glycoprotein first identified in bone but subsequently detected in many other tissues, including, dentin, cartilage, kidney, and vascular tissues.1–3 It is expressed by a wide variety of inflammatory cells (eg, macrophages, T lymphocytes, NK cells), and, to a lesser extent, by ...
Mazen Shaheen, Neal L. Weintraub
openaire +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
The ins and outs of osteopontin [PDF]
OncoImmunology, 2015 The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the
Chiodoni, C. +3 more
openaire +3 more sources
Enhanced biological activity of polymeric osteopontin [PDF]
, 2007 Osteopontin is a multifunctional glycoprotein with roles in immunomodulation, inflammatory response, tissue mineralization, and tissue remodeling, which are mediated primarily through integrins.
Yokosaki, Yasuyuki +5 more
core +1 more source
Biomedicines, 2021 Osteopontin is a member of the proinflammatory cytokine network, a complex system that involves many chemokines, cytokines, and growth factors. The aim of the present study was to study the associations between osteopontin and a large number of ...
Anders Larsson +4 more
doaj +1 more source
TRACP as an Osteopontin Phosphatase [PDF]
Journal of Bone and Mineral Research, 2003 Abstract TRACP is synthesized as a latent proenzyme requiring proteolytic processing to attain maximal phosphatase activity. Excision of an exposed loop domain abolishes the interaction between the loop residue Asp146 and a ligand to the redox-sensitive iron of the active site, most likely Asn91, providing a mechanism for the enzyme ...
Göran, Andersson +7 more
openaire +2 more sources