Results 21 to 30 of about 49,469 (298)
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice. [PDF]
PLoS ONE, 2010 Metastasis to the lung may be the final step in the breast cancer-related morbidity. Conventional therapies such as chemotherapy and surgery are somewhat successful, however, metastasis-related breast cancer morbidity remains high. Thus, a novel approach
Kyeong-Nam Yu +17 more
doaj +1 more source
Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
Cells, 2019 The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function.
Anne-Sophie Lamort +3 more
doaj +1 more source
Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling. [PDF]
PLoS ONE, 2011 Osteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts.
Xin Jin +4 more
doaj +1 more source
Neuroprotection by Osteopontin in Stroke [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2005 Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic functions, including inflammation, cell migration, and antiapoptotic processes. Here we investigate the neuroprotective potential of OPN to reduce cell death using both in vitro and in vivo models of ischemia.
Robert, Meller +9 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Osteopontin in patients with chronic obstructive pulmonary disease and coronary heart disease
Alʹmanah Kliničeskoj Mediciny, 2023 Background: Osteopontin is a protein expressed by various cell types, such as endothelial and epithelial cells, osteoclasts, hepatocytes, smooth muscle cells, activated macrophages, and T-cells.
Natalia A. Suvorova +2 more
doaj +1 more source
The ins and outs of osteopontin [PDF]
OncoImmunology, 2015 The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the
Chiodoni, C. +3 more
openaire +3 more sources
Biomedicines, 2021 Osteopontin is a member of the proinflammatory cytokine network, a complex system that involves many chemokines, cytokines, and growth factors. The aim of the present study was to study the associations between osteopontin and a large number of ...
Anders Larsson +4 more
doaj +1 more source
Tumor Biology, 2017 Osteopontin-c splicing isoform activates ovarian cancer progression features. Imbalanced expression of splicing factors from serine/arginine -rich and heterogeneous ribonucleoproteins families has been correlated with the generation of oncogenic splicing
Durval Santos Marques +4 more
doaj +1 more source
TRACP as an Osteopontin Phosphatase [PDF]
Journal of Bone and Mineral Research, 2003 Abstract TRACP is synthesized as a latent proenzyme requiring proteolytic processing to attain maximal phosphatase activity. Excision of an exposed loop domain abolishes the interaction between the loop residue Asp146 and a ligand to the redox-sensitive iron of the active site, most likely Asn91, providing a mechanism for the enzyme ...
Göran, Andersson +7 more
openaire +2 more sources