Results 11 to 20 of about 52,783 (282)

Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer

Archives of Medical Science, 2020
Introduction Triple-negative breast cancer (TNBC) is associated with lack of expression of estrogen and progesterone receptors and HER2 and is the subgroup of breast cancers with the worst prognosis.
Magdalena Niedolistek, Marta M. Fudalej, Aleksandra Sobiborowicz, Anna Liszcz, Michał P. Budzik, Maciej Sobieraj, Janusz Patera, Aleksandra Czerw, Urszula Religioni, Maria Sobol, Andrzej Deptała, Anna M. Badowska-Kozakiewicz   +11 more
doaj   +2 more sources

Osteopontin Is Associated with Multiple Sclerosis Relapses [PDF]

Biomedicines, 2023
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease ...
Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Ennio Iezzi, Giovanni Galifi, Fortunata Carbone, Teresa Micillo, Ettore Dolcetti, Federica Azzolini, Antonio Bruno, Angela Borrelli, Georgia Mandolesi, Valentina Rovella, Marianna Storto, Annamaria Finardi, Roberto Furlan, Diego Centonze, Giuseppe Matarese   +17 more
doaj   +4 more sources

Osteopontin in chronic obstructive pulmonary disease: Smokers and ex-smokers [PDF]

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: COPD is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between osteopontin, smoking and COPD needs to be clarified.
Ahmed A Ali, Nourane Y. Azab, Ibrahim I. El-Mahalawy, Safaa I. Tayel, Ehab M. Khalifa   +4 more
doaj   +2 more sources

Osteopontin and Clinical Outcomes in Hemodialysis Patients

Biomedicines
Background/Objectives: Chronic kidney disease (CKD) and end-stage kidney disease (ESKD) are significant public health issues, with cardiovascular morbidity and mortality being the leading causes of death in hemodialysis patients.
Claudia Torino, Federico Carbone, Patrizia Pizzini, Sabrina Mezzatesta, Graziella D’Arrigo, Mercedes Gori, Luca Liberale, Margherita Moriero, Cristina Michelauz, Federica Frè, Simone Isoppo, Aurora Gavoci, Federica La Rosa, Alessandro Scuricini, Amedeo Tirandi, Davide Ramoni, Francesca Mallamaci, Giovanni Tripepi, Fabrizio Montecucco, Carmine Zoccali   +19 more
doaj   +2 more sources

Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. [PDF]

PLoS Medicine, 2005
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung.Using oligonucleotide arrays, we identified osteopontin as one of the genes that ...
Annie Pardo, Kevin Gibson, José Cisneros, Thomas J Richards, Yinke Yang, Carina Becerril, Samueal Yousem, Iliana Herrera, Victor Ruiz, Moisés Selman, Naftali Kaminski   +10 more
doaj   +2 more sources

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts.
Kate M. Herum, Andreas Romaine, Ariel Wang, Arne Olav Melleby, Mari E. Strand, Julian Pacheco, Bjørn Braathen, Pontus Dunér, Theis Tønnessen, Ida G. Lunde, Ivar Sjaastad, Cord Brakebusch, Andrew D. McCulloch, Maria F. Gomez, Cathrine R. Carlson, Geir Christensen   +15 more
doaj   +1 more source

Assessing the Level and Diagnostic Accuracy of Osteopontin and Oral Health Status in Periodontitis Patients with/without Type-2 Diabetes Mellitus

Brazilian Dental Science, 2022
Objective: Periodontitis is a multifactorial inflammatory disease usually terminated with tooth loss when untreated. Type-2 diabetes mellitus (T2DM) have shown to exacerbate periodontitis.
Ahmed Makki A. Al-Qarakhli, Firas B. Al-Taweel, Lubaba A. Abdul Ameer, Saif S. Saliem, Ali A. Abdulkareem   +4 more
doaj   +1 more source

Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface

Frontiers in Cell and Developmental Biology, 2023
Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines, Michelle S. Klausner, Violet S. Patterson, Stephen J. Renaud, Stephen J. Renaud   +4 more
doaj   +1 more source

Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury

Disease Models & Mechanisms, 2013
SUMMARY Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests ...
Kitipong Uaesoontrachoon, Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel   +3 more
doaj   +1 more source

Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]

, 2011
Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg, Amann, B., Amann, Barbara, Hofmaier, F., Eberhardt Christina, Hauck Stefanie M., Barbara Amann, Hofmaier Florian, Christina Eberhardt, Florian Hofmaier, Eberhardt, Christina, Hauck, S.M., Cornelia A Deeg, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Eberhardt, C., Hofmaier, Florian, Deeg, C.A.   +21 more
core   +2 more sources