Results 11 to 20 of about 49,469 (298)

Osteopontin in Pulmonary Hypertension

Biomedicines, 2023
Pulmonary hypertension (PH) is a pathological condition with multifactorial etiology, which is characterized by elevated pulmonary arterial pressure and pulmonary vascular remodeling.
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov   +4 more
doaj   +8 more sources

Osteopontin in chronic obstructive pulmonary disease: Smokers and ex-smokers

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: COPD is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between osteopontin, smoking and COPD needs to be clarified.
Ahmed A Ali, Nourane Y. Azab, Ibrahim I. El-Mahalawy, Safaa I. Tayel, Ehab M. Khalifa   +4 more
doaj   +2 more sources

Mesothelin and osteopontin [PDF]

European Respiratory Journal, 2013
From the Authors: We would like to thank Gunnar Hillerdal for his interest in our article 1 and for giving us the opportunity to make some comments regarding multimodality therapy and early stage disease. Sugarbaker et al . 2 reported a groundbreaking result in 1999: patients with early stage malignant pleural mesothelioma (MPM) had a 5-year ...
Pantazopoulos, I., Xanthos, T., Boura, P., Syrigos, K.   +3 more
openaire   +6 more sources

Osteopontin and Clinical Outcomes in Hemodialysis Patients

Biomedicines
Background/Objectives: Chronic kidney disease (CKD) and end-stage kidney disease (ESKD) are significant public health issues, with cardiovascular morbidity and mortality being the leading causes of death in hemodialysis patients.
Claudia Torino, Federico Carbone, Patrizia Pizzini, Sabrina Mezzatesta, Graziella D’Arrigo, Mercedes Gori, Luca Liberale, Margherita Moriero, Cristina Michelauz, Federica Frè, Simone Isoppo, Aurora Gavoci, Federica La Rosa, Alessandro Scuricini, Amedeo Tirandi, Davide Ramoni, Francesca Mallamaci, Giovanni Tripepi, Fabrizio Montecucco, Carmine Zoccali   +19 more
doaj   +2 more sources

Osteopontin in Cardiovascular Diseases [PDF]

Biomolecules, 2021
Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally. These findings suggest the need to reconsider cardiovascular risk and optimal medical therapy.
Kohsuke Shirakawa, Motoaki Sano
openaire   +3 more sources

Osteopontin [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Osteopontin is an arginine-glycine–aspartate (RGD) containing adhesive glycoprotein first identified in bone but subsequently detected in many other tissues, including, dentin, cartilage, kidney, and vascular tissues.1–3 It is expressed by a wide variety of inflammatory cells (eg, macrophages, T lymphocytes, NK cells), and, to a lesser extent, by ...
Mazen Shaheen, Neal L. Weintraub
openaire   +1 more source

Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke

Scientific Reports, 2022
Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain barrier (BBB).
Daniel Spitzer, Tim Puetz, Moritz Armbrust, Maika Dunst, Jadranka Macas, Florian Croll, Karl-Heinz Plate, Yvonne Reiss, Stefan Liebner, Patrick N. Harter, Sylvaine Guérit, Kavi Devraj   +11 more
doaj   +1 more source

Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury

Disease Models & Mechanisms, 2013
SUMMARY Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests ...
Kitipong Uaesoontrachoon, Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel   +3 more
doaj   +1 more source

Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]

, 2011
Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg, Amann, B., Amann, Barbara, Hofmaier, F., Eberhardt Christina, Hauck Stefanie M., Barbara Amann, Hofmaier Florian, Christina Eberhardt, Florian Hofmaier, Eberhardt, Christina, Hauck, S.M., Cornelia A Deeg, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Eberhardt, C., Hofmaier, Florian, Deeg, C.A.   +21 more
core   +1 more source

Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma

Journal of Hematology & Oncology, 2011
The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis.
Kotsis Vasileios, Alegakis Athanasios, Tsirakis George, Pappa Constantina, Miyakis Spiros, Sfiridaki Aikaterini, Stathopoulos Efstathios, Alexandrakis Michael   +7 more
doaj   +1 more source