Results 11 to 20 of about 54,052 (278)
Osteopontin in Pulmonary Hypertension [PDF]
Biomedicines, 2023 Pulmonary hypertension (PH) is a pathological condition with multifactorial etiology, which is characterized by elevated pulmonary arterial pressure and pulmonary vascular remodeling.
Argen Mamazhakypov +4 more
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Osteopontin Is Associated with Multiple Sclerosis Relapses [PDF]
Biomedicines, 2023 Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease ...
Mario Stampanoni Bassi +17 more
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Context-dependent roles of osteopontin in aging-related neurological disorders [PDF]
Journal of International Medical ResearchOsteopontin (encoded by secreted phosphoprotein 1) is a multifunctional matricellular phosphoglycoprotein that has emerged as an important mediator in the aging nervous system.
Dong Huang, Zhen Zhang, Xili Gong
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Osteopontin from monocyte-derived dendritic cells mediates ozone-induced pulmonary responses in mice [PDF]
Frontiers in ImmunologyIntroductionAsthma is a heterogeneous disease characterized by airway inflammation and hyperresponsiveness (AHR). Ozone, a common air pollutant, induces a neutrophilic phenotype of asthma that is resistant to corticosteroids.
Hiroki Tashiro +6 more
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Osteopontin in Atrial Fibrillation and Atrial Remodeling [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseAtrial fibrillation is the most prevalent sustained cardiac arrhythmia, characterized by limited therapeutic options because of incompletely understood mechanisms of its development.
Argen Mamazhakypov +6 more
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Mesothelin and osteopontin [PDF]
European Respiratory Journal, 2013 From the Authors: We would like to thank Gunnar Hillerdal for his interest in our article 1 and for giving us the opportunity to make some comments regarding multimodality therapy and early stage disease. Sugarbaker et al . 2 reported a groundbreaking result in 1999: patients with early stage malignant pleural mesothelioma (MPM) had a 5-year ...
Pantazopoulos, I. +3 more
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Clinical and Molecular Implications of Osteopontin in Heart Failure
Current Issues in Molecular Biology, 2022 The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners ...
Argen Mamazhakypov +4 more
doaj +1 more source
BMC Geriatrics, 2021 Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang +5 more
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Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. [PDF]
PLoS Medicine, 2005 Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung.Using oligonucleotide arrays, we identified osteopontin as one of the genes that ...
Annie Pardo +10 more
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Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts.
Kate M. Herum +15 more
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