Osteopontin Is Associated with Multiple Sclerosis Relapses
Biomedicines, 2023 Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease ...
Mario Stampanoni Bassi +17 more
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Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface
Frontiers in Cell and Developmental Biology, 2023 Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines +4 more
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Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer
Archives of Medical Science, 2020 Introduction Triple-negative breast cancer (TNBC) is associated with lack of expression of estrogen and progesterone receptors and HER2 and is the subgroup of breast cancers with the worst prognosis.
Magdalena Niedolistek +11 more
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Scientific Reports, 2022 Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain barrier (BBB).
Daniel Spitzer +11 more
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Disease Models & Mechanisms, 2013 SUMMARY Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests ...
Kitipong Uaesoontrachoon +3 more
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High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]
, 2018 Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V. +9 more
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Osteopontin in chronic obstructive pulmonary disease: Smokers and ex-smokers
Egyptian Journal of Chest Disease and Tuberculosis, 2015 Background: COPD is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between osteopontin, smoking and COPD needs to be clarified.
Ahmed A Ali +4 more
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Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling. [PDF]
PLoS ONE, 2011 Osteopontin is known to play important roles in various diseases including vascular disorders. However, little is known about its expression and function in vascular adventitial fibroblasts.
Xin Jin +4 more
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Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]
, 2011 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne +3 more
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Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]
, 2016 In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R +7 more
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