Results 1 to 10 of about 39,980 (117)
Osteopontin from monocyte-derived dendritic cells mediates ozone-induced pulmonary responses in mice [PDF]
Frontiers in ImmunologyIntroductionAsthma is a heterogeneous disease characterized by airway inflammation and hyperresponsiveness (AHR). Ozone, a common air pollutant, induces a neutrophilic phenotype of asthma that is resistant to corticosteroids.
Hiroki Tashiro +6 more
doaj +2 more sources
Serum osteopontin as a prognostic biomarker in acute exacerbations of chronic obstructive pulmonary disease [PDF]
Frontiers in ImmunologyOsteopontin, a phosphorylated glycoprotein, is highly expressed in lung tissues and is elevated in inflammatory diseases. However, its role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains unclear.
Kai-Shu Ma +10 more
doaj +2 more sources
Clinical and Molecular Implications of Osteopontin in Heart Failure
Current Issues in Molecular Biology, 2022 The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners ...
Argen Mamazhakypov +4 more
doaj +1 more source
Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. [PDF]
PLoS Medicine, 2005 Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung.Using oligonucleotide arrays, we identified osteopontin as one of the genes that ...
Annie Pardo +10 more
doaj +2 more sources
BMC Geriatrics, 2021 Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang +5 more
doaj +1 more source
Brazilian Dental Science, 2022 Objective: Periodontitis is a multifactorial inflammatory disease usually terminated with tooth loss when untreated. Type-2 diabetes mellitus (T2DM) have shown to exacerbate periodontitis.
Ahmed Makki A. Al-Qarakhli +4 more
doaj +1 more source
Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts.
Kate M. Herum +15 more
doaj +1 more source
Osteopontin Is Associated with Multiple Sclerosis Relapses
Biomedicines, 2023 Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease ...
Mario Stampanoni Bassi +17 more
doaj +1 more source
Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface
Frontiers in Cell and Developmental Biology, 2023 Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines +4 more
doaj +1 more source
Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer
Archives of Medical Science, 2020 Introduction Triple-negative breast cancer (TNBC) is associated with lack of expression of estrogen and progesterone receptors and HER2 and is the subgroup of breast cancers with the worst prognosis.
Magdalena Niedolistek +11 more
doaj +1 more source