Osteopontin from monocyte-derived dendritic cells mediates ozone-induced pulmonary responses in mice [PDF]
Frontiers in ImmunologyIntroductionAsthma is a heterogeneous disease characterized by airway inflammation and hyperresponsiveness (AHR). Ozone, a common air pollutant, induces a neutrophilic phenotype of asthma that is resistant to corticosteroids.
Hiroki Tashiro +6 more
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Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma [PDF]
Journal of Hematology & Oncology, 2011 The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis.
Kotsis Vasileios +7 more
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Serum osteopontin as a prognostic biomarker in acute exacerbations of chronic obstructive pulmonary disease [PDF]
Frontiers in ImmunologyOsteopontin, a phosphorylated glycoprotein, is highly expressed in lung tissues and is elevated in inflammatory diseases. However, its role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains unclear.
Kai-Shu Ma +10 more
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FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation, and metastasis via osteopontin/CD44 pathway [PDF]
Journal of Translational Medicine, 2012 Background Nasopharyngeal carcinoma (NPC) is well-known for its highly metastatic characteristics, but little is known of its molecular mechanisms. New biomarkers that predict clinical outcome, in particular the ability of the primary tumor to develop ...
Chen Chang-Han +12 more
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Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. [PDF]
, 2011 BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles.
Arjomandi, Mehrdad +5 more
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Clinical and Molecular Implications of Osteopontin in Heart Failure
Current Issues in Molecular Biology, 2022 The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners ...
Argen Mamazhakypov +4 more
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BMC Geriatrics, 2021 Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang +5 more
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Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. [PDF]
PLoS Medicine, 2005 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung.
Annie Pardo +10 more
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Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts.
Kate M. Herum +15 more
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Brazilian Dental Science, 2022 Objective: Periodontitis is a multifactorial inflammatory disease usually terminated with tooth loss when untreated. Type-2 diabetes mellitus (T2DM) have shown to exacerbate periodontitis.
Ahmed Makki A. Al-Qarakhli +4 more
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