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Osteopontin in Pulmonary Hypertension [PDF]
Biomedicines, 2023 Pulmonary hypertension (PH) is a pathological condition with multifactorial etiology, which is characterized by elevated pulmonary arterial pressure and pulmonary vascular remodeling.
Argen Mamazhakypov +4 more
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Osteopontin from monocyte-derived dendritic cells mediates ozone-induced pulmonary responses in mice [PDF]
Frontiers in ImmunologyIntroductionAsthma is a heterogeneous disease characterized by airway inflammation and hyperresponsiveness (AHR). Ozone, a common air pollutant, induces a neutrophilic phenotype of asthma that is resistant to corticosteroids.
Hiroki Tashiro +6 more
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Context-dependent roles of osteopontin in aging-related neurological disorders [PDF]
Journal of International Medical ResearchOsteopontin (encoded by secreted phosphoprotein 1) is a multifunctional matricellular phosphoglycoprotein that has emerged as an important mediator in the aging nervous system.
Dong Huang, Zhen Zhang, Xili Gong
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Osteopontin is an arginine-glycine–aspartate (RGD) containing adhesive glycoprotein first identified in bone but subsequently detected in many other tissues, including, dentin, cartilage, kidney, and vascular tissues.1–3 It is expressed by a wide variety of inflammatory cells (eg, macrophages, T lymphocytes, NK cells), and, to a lesser extent, by ...
Lucy Liaw +2 more
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Osteopontin in Cardiovascular Diseases [PDF]
Biomolecules, 2021 Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally. These findings suggest the need to reconsider cardiovascular risk and optimal medical therapy.
Motoaki Sano, Kohsuke Shirakawa
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Osteopontin in Atrial Fibrillation and Atrial Remodeling [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseAtrial fibrillation is the most prevalent sustained cardiac arrhythmia, characterized by limited therapeutic options because of incompletely understood mechanisms of its development.
Argen Mamazhakypov +6 more
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Serum osteopontin as a prognostic biomarker in acute exacerbations of chronic obstructive pulmonary disease [PDF]
Frontiers in ImmunologyOsteopontin, a phosphorylated glycoprotein, is highly expressed in lung tissues and is elevated in inflammatory diseases. However, its role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains unclear.
Kai-Shu Ma +10 more
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Mesothelin and osteopontin [PDF]
European Respiratory Journal, 2013 From the Authors: We would like to thank Gunnar Hillerdal for his interest in our article 1 and for giving us the opportunity to make some comments regarding multimodality therapy and early stage disease. Sugarbaker et al . 2 reported a groundbreaking result in 1999: patients with early stage malignant pleural mesothelioma (MPM) had a 5-year ...
Pantazopoulos, I. +3 more
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Clinical and Molecular Implications of Osteopontin in Heart Failure
Current Issues in Molecular Biology, 2022 The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners ...
Argen Mamazhakypov +4 more
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BMC Geriatrics, 2021 Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang +5 more
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