Results 41 to 50 of about 75,213 (253)
Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling [PDF]
, 2011 Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in
A Tagariello +48 more
core +2 more sources
The Yin-Yang of osteopontin in nervous system diseases: damage versus repair
Neural Regeneration Research, 2021 Osteopontin is a broadly expressed pleiotropic protein, and is attracting increased attention because of its role in the pathophysiology of several inflammatory, degenerative, autoimmune, and oncologic diseases.
Giuseppe Cappellano +9 more
doaj +1 more source
A perfusion culture system for assessing bone marrow stromal cell differentiation on PLGA scaffolds for bone repair [PDF]
, 2018 Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow
Alini, Mauro +5 more
core +2 more sources
Endocrine Oncology, 2023 Objective: Thyroid cancer can be detected in 5–10% of patients with thyroid nodules. Management may be a challenge if fine-needle aspiration biopsy yields Bethesda III findings. Most of these cases undergo surgery and are ultimately found benign. Our aim
T U Kars, M Kulaksızoğlu, İ Kılınç
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2013 Purpose: In malignant pleural mesothelioma (MPM), early assessment of disease status is important. We evaluated the role of mesothelin and osteopontin biomarkers in distinguishing MPM from benign pleural disease. We also, evaluated whether mesothelin and
Fawzy M. Amany +6 more
doaj +1 more source
MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]
, 2017 MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa +9 more
core +2 more sources
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]
, 2017 OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M +16 more
core +6 more sources