Results 61 to 70 of about 54,052 (278)

Perbaikan Mutu Semen Beku Sapi Perah Friesian Holstein melalui Penambahan Osteopontin dalam Media Pembekuan [PDF]

, 2012
Osteopontin adalah protein yang memegang peranan penting dalam keberhasilan fertilisasi. Penelitian ini bertujuan untuk menjelaskan mekanisme peningkatan fertilisasi sapi menggunakan spermatozoa yang disimpan dalam media pembekuan dengan penambahan ...
Abdul Samik, Dr., M.Si., Drh., Tatik Hernawati, M.Si, Drh, Tri Wahyu Suprayogi, M.Si., Drh.   +2 more
core   +1 more source

The effect of osteopontin and osteopontin-derived peptides on preterm brain injury [PDF]

Journal of Neuroinflammation, 2014
Osteopontin (OPN) is a highly phosphorylated sialoprotein and a soluble cytokine that is widely expressed in a variety of tissues, including the brain. OPN and OPN-derived peptides have been suggested to have potential neuroprotective effects against ischemic brain injury, but their role in preterm brain injury is unknown.We used a hypoxia-ischemia (HI)
Albertsson, Anna-Maj, Zhang, Xiaoli, Bi, Dan, Nair, Syam, Qiao, Lili, Hagberg, Henrik, Mallard, Carina, Wang, Xiaoyang, Leavenworth, Jianmei, Cantor, Harvey   +9 more
openaire   +4 more sources

Osteopontin structure and function [PDF]

, 1998
Thesis (Ph. D.)--University of Washington, 1998Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling. There are several structural domains in osteopontin of particular interest.
Smith, Laura Lee
core  

Osteopontin presentation affects cell adhesion-Influence of underlying surface chemistry and nanopatterning of osteopontin.

, 2010
Osteopontin is a promising coating material for biomaterials, being important both in remodeling and formation of mineralized tissue and in immunological responses.
Esben S. Sørensen, Jenny Malmström, Brian Christensen, Jette Lovmand, Mogens Duch, Duncan S. Sutherland, Lovmand, Jette, Malmström, Jenny, Sørensen, Esben S, Duch, Mogens, Sutherland, Duncan S, Christensen, Brian   +11 more
core   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers

BMC Cardiovascular Disorders, 2012
Background Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates
Bishop Emma, Theophilus Eugenia H, Fearon Ian M   +2 more
doaj   +1 more source

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the αXβ2 Integrin [PDF]

The Journal of Immunology, 2009
Abstract Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process ...
Schack, Lotte, Stapulionis, Romualdas, Christensen, Brian, Kofod-Olsen, Emil, Sørensen, Uffe B. Skov, Vorup-Jensen, Thomas; id_orcid 0000-0002-4140-6563, Sørensen, Esben S; id_orcid 0000-0002-7050-3354, Höllsberg, Per   +7 more
openaire   +3 more sources

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Calcium-phosphate-osteopontin particles for caries control

, 2016
Caries is caused by acid production in biofilms on dental surfaces. Preventing caries therefore involves control of microorganisms and/or the acid produced.
Rikke L. Meyer (144812), Jakob Olsen (2470144), Jonas Skovgaard (2470141), Peter L. Wejse (144795), Sebastian Schlafer (144783), Duncan S. Sutherland (144806), Bente Nyvad (144799), Henrik Birkedal (144810)   +7 more
core   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source