Results 61 to 70 of about 52,783 (282)

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Different effects of global osteopontin and macrophage osteopontin in glomerular injury [PDF]

American Journal of Physiology-Renal Physiology, 2018
Osteopontin (OPN) is a pro-and anti-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidneys. To characterize further the role of OPN in kidney injury
Jessica, Trostel, Luan D, Truong, Carlos, Roncal-Jimenez, Makoto, Miyazaki, Shinobu, Miyazaki-Anzai, Masanari, Kuwabara, Rachel, McMahan, Ana, Andres-Hernando, Yuka, Sato, Thomas, Jensen, Miguel A, Lanaspa, Richard J, Johnson, Gabriela E, Garcia   +12 more
openaire   +2 more sources

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

The effect of osteopontin and osteopontin-derived peptides on preterm brain injury [PDF]

Journal of Neuroinflammation, 2014
Osteopontin (OPN) is a highly phosphorylated sialoprotein and a soluble cytokine that is widely expressed in a variety of tissues, including the brain. OPN and OPN-derived peptides have been suggested to have potential neuroprotective effects against ischemic brain injury, but their role in preterm brain injury is unknown.We used a hypoxia-ischemia (HI)
Albertsson, Anna-Maj, Zhang, Xiaoli, Bi, Dan, Nair, Syam, Qiao, Lili, Hagberg, Henrik, Mallard, Carina, Wang, Xiaoyang, Leavenworth, Jianmei, Cantor, Harvey   +9 more
openaire   +4 more sources

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring [PDF]

, 2008
Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis.
Mori, Ryoichi, Shaw, T.J, Tanya J. Shaw, Shaw, Tanya J., Martin, Paul, Shaw, TJ, Mori, R, Shaw, Tanya J, Paul Martin, Martin, P, Ryoichi Mori   +10 more
core   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers

BMC Cardiovascular Disorders, 2012
Background Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates
Bishop Emma, Theophilus Eugenia H, Fearon Ian M   +2 more
doaj   +1 more source

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the αXβ2 Integrin [PDF]

The Journal of Immunology, 2009
Abstract Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how OPN may enhance this innate immune process ...
Schack, Lotte, Stapulionis, Romualdas, Christensen, Brian, Kofod-Olsen, Emil, Sørensen, Uffe B. Skov, Vorup-Jensen, Thomas; id_orcid 0000-0002-4140-6563, Sørensen, Esben S; id_orcid 0000-0002-7050-3354, Höllsberg, Per   +7 more
openaire   +3 more sources

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source