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Association of osteopontin with osteoarthritis
Rheumatology International, 2014The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly affects the older people. OA is becoming one of the major non-fatal health burdens of the world. The etiology of OA is mostly unclear, and it cannot be cured totally.
Chao, Cheng +2 more
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Role of osteopontin in osteosarcoma
Medical Oncology, 2014The primary bone malignancy osteosarcoma (OS) is a painful health burden, of which treatment remains a challenging problem. Identification of specific tumor biomarkers may help to investigate and develop the novel effective therapeutic approaches that have specific molecular target for the treatment of patients with OS.
Yu-Sheng, Li +3 more
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Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice
Nephron Experimental Nephrology, 1999Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While numerous activities have been ascribed to OPN in vitro, and several in vivo functions have been suggested for the molecule, including much attention focused recently on OPN in different pathologies, the actual role that the protein
S R, Rittling, D T, Denhardt
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Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin
Calcified Tissue International, 2005Ectopic calcification is a major cause of bioprosthetic heart valve failure. New therapeutic opportunities are offered by the growing understanding that ectopic calcification is an actively regulated process involving several key gene products. One of these products, osteopontin (OPN), is a glycosylated phosphoprotein previously shown to inhibit ...
Rachit, Ohri +3 more
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Osteopontin and cardiovascular system
Molecular and Cellular Biochemistry, 2006A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress and similar stimuli in the heart, integrates the inter-ECM signal transduction network of component cells, and maintains efficient contractility through quantitative and qualitative control of extracellular matrix (ECM) proteins. In particular, OPN is re-expressed
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The Role of Osteopontin in Neurodegenerative Diseases
Journal of Alzheimer's Disease, 2011Osteopontin (OPN) was shown to be involved in inflammatory and degenerative processes of the nervous system. In multiple sclerosis, the role of OPN has been studied in the inflammatory phase, where it was shown that the protein levels increase during disease relapses.
Carecchio M., Comi C.
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Osteopontin in macrophage function
Expert Reviews in Molecular Medicine, 2011The secreted phosphorylated protein osteopontin (OPN) is expressed in a variety of tissues and bodily fluids, and is associated with pathologies including tissue injury, infection, autoimmune disease and cancer. Macrophages are ubiquitous, heterogeneous cells that mediate aspects of cell and tissue damage in all these pathologies. Here, the role of OPN
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Differential osteopontin functions: The role of osteopontin isoforms
Hepatology, 2015Jason D, Coombes, Wing-Kin, Syn
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Nihon rinsho. Japanese journal of clinical medicine, 2003
Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis.
Masaki, Noda +4 more
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Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis.
Masaki, Noda +4 more
openaire +1 more source