Results 241 to 250 of about 52,783 (282)
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Drug News & Perspectives, 1998
Although osteopontin (OP) has been shown to play a role in bone mineralization and to mediate bone cell adhesion, its function in other tissues is not yet known. The sequences of OP from seven species have been reported; some of the sequences that are conserved in all seven species and their functions are mentioned.
M A, Chellaiah, K A, Hruska
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Although osteopontin (OP) has been shown to play a role in bone mineralization and to mediate bone cell adhesion, its function in other tissues is not yet known. The sequences of OP from seven species have been reported; some of the sequences that are conserved in all seven species and their functions are mentioned.
M A, Chellaiah, K A, Hruska
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Thrombin cleavage of osteopontin initiates osteopontin’s tumor‐promoting activity
Journal of Thrombosis and Haemostasis, 2022Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α4 β1 and α9 β1 integrins.Thrombin cleavage-resistant OPNR153A knock-in (OPN-KI) mice were generated and compared to OPN ...
Sameera Peraramelli +12 more
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Osteopontin and Mucosal Protection
Journal of Dental Research, 2006Protection of mucosal tissues of the oral cavity, intestines, respiratory tract, and urogenital tract from the constant challenge of pathogens is achieved by the combined barrier function of the lining epithelia and specialized immune cells. Recent studies have indicated that osteopontin (OPN) has a pivotal role in the development of immune responses ...
J, Sodek +2 more
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Association of osteopontin with osteoarthritis
Rheumatology International, 2014The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly affects the older people. OA is becoming one of the major non-fatal health burdens of the world. The etiology of OA is mostly unclear, and it cannot be cured totally.
Chao, Cheng +2 more
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Osteopontin (OPN) is a heavily post-translationally modified protein with a molecular weight of 44-70 kDa, depending on the degree of glycosylation. OPN is involved in various biological processes, including bone remodeling, immune response, cell adhesion, migration, and survival.
Alpana, Kumari +2 more
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Alpana, Kumari +2 more
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Role of osteopontin in osteosarcoma
Medical Oncology, 2014The primary bone malignancy osteosarcoma (OS) is a painful health burden, of which treatment remains a challenging problem. Identification of specific tumor biomarkers may help to investigate and develop the novel effective therapeutic approaches that have specific molecular target for the treatment of patients with OS.
Yu-Sheng, Li +3 more
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Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice
Nephron Experimental Nephrology, 1999Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While numerous activities have been ascribed to OPN in vitro, and several in vivo functions have been suggested for the molecule, including much attention focused recently on OPN in different pathologies, the actual role that the protein
S R, Rittling, D T, Denhardt
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Osteopontin and cardiovascular system
Molecular and Cellular Biochemistry, 2006A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress and similar stimuli in the heart, integrates the inter-ECM signal transduction network of component cells, and maintains efficient contractility through quantitative and qualitative control of extracellular matrix (ECM) proteins. In particular, OPN is re-expressed
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Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin
Calcified Tissue International, 2005Ectopic calcification is a major cause of bioprosthetic heart valve failure. New therapeutic opportunities are offered by the growing understanding that ectopic calcification is an actively regulated process involving several key gene products. One of these products, osteopontin (OPN), is a glycosylated phosphoprotein previously shown to inhibit ...
Rachit, Ohri +3 more
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The Role of Osteopontin in Neurodegenerative Diseases
Journal of Alzheimer's Disease, 2011Osteopontin (OPN) was shown to be involved in inflammatory and degenerative processes of the nervous system. In multiple sclerosis, the role of OPN has been studied in the inflammatory phase, where it was shown that the protein levels increase during disease relapses.
CARECCHIO M, COMI, Cristoforo
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