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Journal of Hepatology, 2006 BACKGROUND/AIMS - Osteopontin has been implicated in numerous physiopathological events. Osteopontin expression in normal and fibrotic liver and liver fibrogenesis in osteopontin-deficient mice were studied. Methods: Fibrosis was induced in mice and rats
Ian A Darby +2 more
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Drug News & Perspectives, 1998
Although osteopontin (OP) has been shown to play a role in bone mineralization and to mediate bone cell adhesion, its function in other tissues is not yet known. The sequences of OP from seven species have been reported; some of the sequences that are conserved in all seven species and their functions are mentioned.
M A, Chellaiah, K A, Hruska
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Although osteopontin (OP) has been shown to play a role in bone mineralization and to mediate bone cell adhesion, its function in other tissues is not yet known. The sequences of OP from seven species have been reported; some of the sequences that are conserved in all seven species and their functions are mentioned.
M A, Chellaiah, K A, Hruska
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Critical Reviews in Oral Biology & Medicine, 2000
Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. OPN is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell ...
J, Sodek, B, Ganss, M D, McKee
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Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. OPN is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell ...
J, Sodek, B, Ganss, M D, McKee
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Thrombin cleavage of osteopontin initiates osteopontin’s tumor‐promoting activity
Journal of Thrombosis and Haemostasis, 2022Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α4 β1 and α9 β1 integrins.Thrombin cleavage-resistant OPNR153A knock-in (OPN-KI) mice were generated and compared to OPN ...
Sameera Peraramelli +12 more
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The Nature and Significance of Osteopontin
Connective Tissue Research, 1989Osteopontin is an acidic glycoprotein of about 41,500 daltons that has been isolated from rat, human and bovine bone. It is rich in aspartic acid, glutamic acid and serine and contains about 30 monosaccharides, including 10 sialic acids. Several types of data suggest that the carbohydrate is present as 1 N-glycoside and 5-6 O-glycosides while the ...
William T Butler
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Osteopontin and Mucosal Protection
Journal of Dental Research, 2006Protection of mucosal tissues of the oral cavity, intestines, respiratory tract, and urogenital tract from the constant challenge of pathogens is achieved by the combined barrier function of the lining epithelia and specialized immune cells. Recent studies have indicated that osteopontin (OPN) has a pivotal role in the development of immune responses ...
J, Sodek +2 more
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Nuclear osteopontin-c is a prognostic breast cancer marker
British Journal of Cancer, 2015 Background: Although Osteopontin has been known as a marker for cancer progression, the elevated production of this cytokine is not specific for cancer.
Carl Blomqvist +2 more
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Osteopontin (OPN) is a heavily post-translationally modified protein with a molecular weight of 44-70 kDa, depending on the degree of glycosylation. OPN is involved in various biological processes, including bone remodeling, immune response, cell adhesion, migration, and survival.
Alpana, Kumari +2 more
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Alpana, Kumari +2 more
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