Results 231 to 240 of about 49,469 (298)

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, Volume 183, Issue 12, Page 3321-3339, June 2026.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Novel biomarkers for early detection of HCC in patients with MASLD or ALD. [PDF]

Hepatol Commun
Deodhar S, Jarrah M, Parikh ND, Al-Hasan M, Gopal P, Singal AG.   +5 more
europepmc   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, Volume 117, Issue 6, Page 1748-1765, June 2026.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

Loss of Nonhematopoietic Osteopontin Weakens the Intestinal Barrier and Alters the Microbiome and Metabolome in Mice. [PDF]

Gastro Hep Adv
Hirano T, Wagatsuma K, Shimomori Y, Akita K, Nakamura T, Yamakawa T, Yokoyama Y, Kurumi H, Ishigami K, Nagaishi K, Nakase H.   +10 more
europepmc   +1 more source

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, Volume 59, Issue 6, June 2026.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Aging Regulates Receptivity by Modulating the Expression of Osteopontin and HOXA10 in the Human Endometrium. [PDF]

J Clin Med
Makrygiannakis F, Marmara M, Vrekoussis T, Nikitovic D, Makrigiannakis A, Berdiaki A.   +5 more
europepmc   +1 more source

Characterization of Urinary Kidney Injury Biomarker Profiles in Healthy Japanese Subjects With Reference to a Counterpart US Study

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Drug‐induced kidney injury should be monitored throughout the drug development process to ensure patient safety. Standard kidney injury biomarkers may not always correlate with subtle microscopic histopathological kidney injury. Standard biomarkers are insufficiently sensitive for detection of early‐phase kidney injury.
Takehiko Sambe, Takuya Mizukami, Nicholas M. P. King, Gary Friedman, Stefan Sultana, Chieko Muto, Masanori Hizue, Yoichi Ii   +7 more
wiley   +1 more source

VCAM-1 and Osteopontin Link Hemodynamic Alteration to Fibrosis in Portal Hypertension. [PDF]

Cell Mol Gastroenterol Hepatol
Sano A, Guo Q, Ibrahim SH.
europepmc   +1 more source

Single‐Cell RNA‐Seq Combined With Bulk RNA‐Seq Revealed the Involvement of Pancreatic Cancer Tissue‐Resident Macrophages in Tumour Progression and the Immunotherapy Response

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer remains a highly lethal malignancy with limited therapeutic efficacy and untapped immunotherapeutic potential, largely constrained by immune cell heterogeneity in the tumour microenvironment. Tumour‐associated macrophages (TAMs), especially tissue‐resident macrophages (TRMs), exert complex regulatory roles in tumour ...
Bin Wu, Chundong Hu, Fengchun Lu
wiley   +1 more source