Results 211 to 220 of about 462,772 (320)

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus   +8 more
wiley   +1 more source

Nocturia ≥ 3/Night and 5‐Year Fragility Fracture Risk in Older Urology Outpatients

open access: yesGeriatrics &Gerontology International, Volume 26, Issue 10, October 2026.
Among older urology outpatients, nocturia ≥ 3/night was associated with higher standardized 5‐year fragility‐fracture risk (9.8% vs. 4.8%; adjusted sHR 2.11). A single nocturia question may serve as a simple clinical prompt for falls and bone‐health assessment.
Kunihisa Nezu   +3 more
wiley   +1 more source

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin   +10 more
wiley   +1 more source

Liver fat fraction negatively correlates with lumbar BMD in normal body mass index postmenopausal women: mediated by bone marrow fat. [PDF]

open access: yesFront Endocrinol (Lausanne)
Gao L   +9 more
europepmc   +1 more source

GPX4‐Mediated Inhibition of Ferroptosis by Sodium Selenite Ameliorates Bone Metabolic Disorders in Ovariectomized Mice

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Postmenopausal osteoporosis (PMOP) and its associated fracture complications have emerged as pressing public health challenges due to rapidly accelerating global population ageing. The functional decline of bone marrow mesenchymal stem cells (BMSCs) under elevated oxidative stress is a recognised pathogenic cornerstone of PMOP, positioning ...
Wei Luo   +7 more
wiley   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

open access: yesOrthopaedic Surgery, Volume 18, Issue 10, Page 2015-2031, October 2026.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang   +84 more
wiley   +1 more source

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