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Two complementary notions need to be considered in the definition of osteoporosis: a reduction in bone mineral density and the occurrence of fracture. Bone mineral density is an established determinant of the risk of future fracture, but current interventions are most usefully targeted before bone density has fallen to the levels at which fractures ...
C, Cooper, A, Aihie
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Wallace, Ian+2 more
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Pharmacogenetics of osteoporosis [PDF]
Osteoporosis is a complex bone disorder with a strong genetic basis. The genetics of osteoporosis encompasses two main areas: genetics of disease susceptibility and pharmacogenetics of drug response. The former has been widely studied in the past few decades, while the latter is still largely untouched.
MARINI, FRANCESCA, BRANDI, MARIA LUISA
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Genetics of Osteoporosis [PDF]
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density and other determinants of fracture risk, such as ultrasound properties of bone, skeletal geometry, and bone turnover, is high ...
Stuart H. Ralston+1 more
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Objective The class II transactivator (CIITA), encoded by the CIITA gene, controls expression of immune response regulators, which affect bone homeostasis. Previously, we investigated a functional CIITA polymorphism in elderly women.
Vivi FH Jensen+5 more
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Background Sarcopenia and sarcopenic obesity (SO) have a greater impact on the elderly. This study aimed to explore whether there were sex differences in the prevalence and adverse outcomes of sarcopenia and SO in community-dwelling elderly individuals ...
Yanping Du+13 more
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Human Bone Typing Using Quantitative Cone-Beam Computed Tomography
Introduction: Bone typing is crucial to enable the choice of a suitable implant, the surgical technique, and the evaluation of the clinical outcome. Currently, bone typing is assessed subjectively by the surgeon.
Hairong Huang+3 more
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There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic
Nasser M. Al-Daghri+8 more
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Objectives: Older adults with impaired physical function are at risk for further functional decline in part due to limited ability to engage in regular exercise.
Murad H. Taani PhD, MPH, RN+6 more
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