Results 71 to 80 of about 320,830 (257)

Mechanisms and management strategies for exacerbated bone loss following denosumab discontinuation

Frontiers in Aging
Denosumab is a first-line therapy for osteoporosis, yet the rebound increase in bone turnover markers, rapid bone loss, and elevated fracture risk following its discontinuation have become major challenges in clinical management.
Jiancheng Yang, Ming Yang, Yuhong Zeng
doaj   +1 more source

Male Osteoporosis

, 2004
Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men.
Ahmet Rıza Uras, Nihal Özaras, Meltem Esenyel, Saliha Eroğlu Demir   +3 more
core  

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Opportunistic Assessment of Hip Fracture Risk Based on Chest CT

Orthopaedic Surgery
Objective Hip fracture (HF) has been described as the “last fracture of life” in the elderly, so the assessment of HF risk is extremely important. Currently, few studies have examined the relationship between imaging data from chest computed tomography ...
Xiong Yi Wang, Si Min Yun, Wei Feng Liu, Yi Ke Wang, Sheng Pan, You Jia Xu   +5 more
doaj   +1 more source

Pharmacotherapy of osteoporosis

South African Family Practice, 2019
No abstract available.
National Osteoporosis Foundation of South Africa (NOFSA)
doaj   +1 more source

Comparison of Osteoporosis in Two Different Regions of Turkey [PDF]

, 2014
Objective: The aim of the study was to investigate the effect of different climate and geographic conditions on bone mineral density. Materials and Methods: The patients who had been examined with Dual X-ray Absorptiometry (DXA) for the suspicion of ...
Kaymaz, Burak, Ferdi Göksel, Erbay, Piril, Goksel, Ferdi, Adam, Gurhan, Umut Hatay Gölge, Komurcu, Erkam, Pırıl Erbay, Erkam Kömürcü, Yunus Güzel, Gürhan Adam, Golge, Umut Hatay, Guzel, Yunus, Burak Kaymaz   +13 more
core   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Expression of Concern on “A Radiographic Study on the Associations of Age and Prevalence of Vertebral Fractures with Abdominal Aortic Calcification in Japanese Postmenopausal Women and Men”

Journal of Osteoporosis, 2022
Journal of Osteoporosis
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Heterogeneity in Lumbar Segmental Bone Mineral Density and Age‐Related Evolution of Whole‐Body Bone Mineral Density: Comprehensive Implications for Osteoporosis Risk Assessment

Orthopaedic Surgery
Objective This study aimed to analyze the bone mineral density (BMD) in various body regions, investigate the effects of age and sex on BMD, and characterize BMD variations among different lumbar segments (L1–L4).
Jia‐Jun Zhang, Xiong‐Yi Wang, Cheng‐Wei Weng, Miao Zheng, You‐Jia Xu   +4 more
doaj   +1 more source