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The Epidemiology of Osteosarcoma
Cancer Treatment and Research, 2009 Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most common primary bone malignancy. The incidence rates and 95% confidence intervals of osteosarcoma for all races and both sexes are 4.0 (3.5-4.6) for the range 0-14 years and 5.0 (4.6-5.6) for the range 0-19 years per year per million persons.
Giulia Ottaviani, Norman Jaffé
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Annals of Oncology, 2010 The successful treatment of patients with osteosarcoma requires close cooperation within an experienced multidisciplinary team including pediatric or medical oncologists, surgeons, pathologists and radiologists. Therefore, therapy should be performed in specialized centers able to provide access to the full spectrum of care.
S S Bielack, S S Bielack, J Ritter
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Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1991
Osteosarcoma includes several distinct varieties. It is therefore essential to rely upon a very specialized pathologist. It is necessary to stage the tumor and to histologically define the oncologic quality of the surgical removal (surgical margins). The limb salvage surgery in osteosarcoma involves several areas of risk: the biopsy, the extension of ...
Campanacci M, RUGGIERI, PIETRO
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Osteosarcoma includes several distinct varieties. It is therefore essential to rely upon a very specialized pathologist. It is necessary to stage the tumor and to histologically define the oncologic quality of the surgical removal (surgical margins). The limb salvage surgery in osteosarcoma involves several areas of risk: the biopsy, the extension of ...
Campanacci M, RUGGIERI, PIETRO
openaire +7 more sources
The Lancet, 1988
Osteosarcoma is the most common bone tumor of children and adolescents. The peak incidence of the disease is in the 15 to 19 year age group. The disease is more commonly seen in males than females. While several factors, including exposure to radiation, genetic disorders such as retinoblastoma, and high rate of bone growth, have been associated with ...
C K, Tebbi, J, Gaeta
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Osteosarcoma is the most common bone tumor of children and adolescents. The peak incidence of the disease is in the 15 to 19 year age group. The disease is more commonly seen in males than females. While several factors, including exposure to radiation, genetic disorders such as retinoblastoma, and high rate of bone growth, have been associated with ...
C K, Tebbi, J, Gaeta
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Current Opinion in Oncology, 1993
Findings from molecular genetic and cytogenetic investigations suggest that mutations in suppressor genes play a key role in osteosarcoma pathogenesis. RB and p53 are frequently involved and are speculated to be indispensable components. Alterations in putative suppressor genes on chromosomes 18q and 3q additionally may be involved in various patterns.
N, Fuchs, K, Winkler
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Findings from molecular genetic and cytogenetic investigations suggest that mutations in suppressor genes play a key role in osteosarcoma pathogenesis. RB and p53 are frequently involved and are speculated to be indispensable components. Alterations in putative suppressor genes on chromosomes 18q and 3q additionally may be involved in various patterns.
N, Fuchs, K, Winkler
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Pediatric Blood & Cancer, 2020
Abstract Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology.
Bree R. Eaton +6 more
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Abstract Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology.
Bree R. Eaton +6 more
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Surgical Pathology Clinics
The diagnosis of osteosarcoma can be challenging, given the diverse histologic patterns, limited biopsy samples, lack of tumor-specific molecular alterations, and necessity for radiologic correlation. This review summarizes the key pathologic features of osteosarcoma subtypes with an emphasis on illustrating radiologic, gross macroscopic, and ...
John M, Gross, Meera, Hameed
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The diagnosis of osteosarcoma can be challenging, given the diverse histologic patterns, limited biopsy samples, lack of tumor-specific molecular alterations, and necessity for radiologic correlation. This review summarizes the key pathologic features of osteosarcoma subtypes with an emphasis on illustrating radiologic, gross macroscopic, and ...
John M, Gross, Meera, Hameed
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2014
Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body. It has a bimodal distribution with peaks in the second decade of life and late adulthood. This chapter will highlight the clinical presentation, diagnosis, and treatment of osteosarcoma.
Drew D, Moore, Hue H, Luu
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Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body. It has a bimodal distribution with peaks in the second decade of life and late adulthood. This chapter will highlight the clinical presentation, diagnosis, and treatment of osteosarcoma.
Drew D, Moore, Hue H, Luu
openaire +2 more sources