From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
オルニチン・トランスカルバミラーゼ(OTC)欠損(spf-ash)マウスへのOTC遺伝子導入
The sparse fur with abnormal skin and hair (spf-ash) mouse is a model for the human X linked hereditary disease， ornithine transcarbamylase (OTC) deficiency. It is characterized by hyperammonemia， orotic aciduria， lower serum citrulline and arginine， and
Shimada, Tokihiko +2 more
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Counselling in practice: Alternatives to OTC Codeine
, 2016 Michelle is 45 years of age, and has been using Nurofen Plus, which she started about a year ago for her back pain. She says in the past six months she has sometimes had to take more than 10 tablets a day.
Seng, Leonard +4 more
core
Beyond the restricted market: OTC devices in the American, European, and Italian legislation
openL’introduzione degli apparecchi acustici Over-The-Counter (OTC) rappresenta una svolta significativa nella gestione della perdita uditiva. Questa tesi analizza la cornice normativa e scientifica che accompagna tali dispositivi negli Stati Uniti, in ...
LAZZARETTI, EMANUELE
core
Pre-emptive treatment in later-onset urea cycle disorders: a clinical perspective on glycerol phenylbutyrate. [PDF]
Orphanet J Rare DisSpada M, Porta F.
europepmc +1 more source
Crossing over: when meiotic recombination impacts linkage-based preimplantation genetic testing for monogenic disorders. [PDF]
F S RepKlein EJ, Christianson MS.
europepmc +1 more source
Genotypic and clinical characteristics of long-term surviving adult patients with urea cycle disorders in Japan. [PDF]
Orphanet J Rare DisKido J, Sugawara K, Yano N, Nakamura K.
europepmc +1 more source
Metabolic mimicry of perioral myoclonia with absences: A signature of thalamocortical instability in childhood-onset ornithine transcarbamylase deficiency. [PDF]
Epileptic DisordBragatti JA, Grigoletto L.
europepmc +1 more source
Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns. [PDF]
Mol TherGinn SL +15 more
europepmc +1 more source