Results 41 to 50 of about 19,281 (203)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Lower bounds for incidences with hypersurfaces

Discrete Analysis, 2016
Lower bounds for incidences with hypersurfaces, Discrete Analysis 2016:16, 14pp. A fundamental result in combinatorial geometry, the Szemerédi-Trotter theorem, states that among any $n$ points and $m$ lines in $\mathbb R^2$ there can be at most $O((mn)^{
Adam Sheffer
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Formation of a heterogeneous group of UAVS with a reasonable number of false and real drones

Радіоелектронні і комп'ютерні системи
The subject of scientific research is the joint use of false and real unmanned aerial vehicles (UAVs) as part of a heterogeneous group of UAVs to perform military tasks. This article aimsto determine the appropriate number of false and real drones (UAVs)
Volodymyr Prymirenko, Andrii Demianiuk, Roman Shevtsov, Serhii Bazilo, Andrey Pilipenko, Mykola Vovchanskyi   +5 more
doaj   +1 more source

Fuglede's conjecture on cyclic groups of order $p^nq$

Discrete Analysis, 2017
Fuglede's conjecture on cyclic groups of order $p^nq$, Discrete Analysis 2017:12, 16 pp. A conjecture of Fuglede from 1974 states that a measurable set $E\subset \mathbb R^n$ of positive Lebesgue measure tiles $\mathbb R^n$ by translations if and only ...
Romanos Diogenes Malikiosis, Mihail N. Kolountzakis   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Chemoreactome prediction of anti-inflammatory, analgesic, ulcerogenic effects of the candidate molecule N-allylimidazole-zinc in comparison with zinc derivatives of nonsteroidal anti-inflammatory drugs

Фармакоэкономика
Background. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for effective and safe pharmacotherapy of inflammation and pain. NSAIDs usually reduce the level of gastroprotective prostaglandin E2 due to cyclooxygenase-1 inhibition.
P. A. Galenko-Yaroshevsky, A. V. Sergeeva, I. Yu. Torshin, A. N. Gromov, I. A. Reyer, O. A. Gromova, B. A. Trofimov, L. N. Parshina, R. A. Murashko, A. V. Zadorozhniy, A. V. Zelenskaya, N. S. Sergeev, Yu. V. Tovkach, O. N. Gulevskaya, I. V. Sholl   +14 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source