Results 71 to 80 of about 17,677 (248)
Complexity results for the gap inequalities for the max-cut problem [PDF]
, 2012 We prove several complexity results about the gap inequalities for the max-cut problem, including (i) the gap-1 inequalities do not imply the other gap inequalities, unless NP=Co NP; (ii) there must exist non-redundant gap inequalities with exponentially
Galli, Laura +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Approximation hardness of dominating set problems in bounded degree graphs
, 2008 We study approximation hardness of the Minimum Dominating Set problem and its variants in undirected and directed graphs. Using a similar result obtained by Trevisan for Minimum Set Cover we prove the first explicit approximation lower bounds for various
Chlebikova, Janka +4 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Applications of cohomology to set theory I: Hausdorff gaps
, 1995 We explore an application of homological algebra to set theoretic objects by developing a cohomology theory for Hausdorff gaps. This leads to a natural equivalence notion for gaps about which we answer questions by constructing many simultaneous gaps ...
Talayco, Daniel E., Daniel E. Talayco
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International Journal of Mathematical Combinatorics, Vol.2A [PDF]
, 2008 The International J.Mathematical Combinatorics (ISSN 1937-1055) is a fully refereed international journal, sponsored by the MADIS of Chinese Academy of Sciences and published in USA quarterly comprising 460 pages approx.
Mao, Linfan (Editor-in-Chief)
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Six Permutation Patterns Force Quasirandomness
Discrete AnalysisSix permutation patterns force quasirandomness, Discrete Analysis 2024:8, 26 pp. Quasirandomness is a major theme in combinatorics, with several important applications.
Gabriel Crudele +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2000 This paper is a survey of feedback set problems (FSP). FSP originated from applications in combinatorial circuit design, but have found their way into numerous other applications, such as deadlock prevention in operating systems, constraint satisfaction ...
FESTA, PAOLA +2 more
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