Results 81 to 90 of about 17,677 (248)

The expressibility of functions on the Boolean domain, with applications to Counting CSPs [PDF]

, 2013
An important tool in the study of the complexity of Constraint Satisfaction Problems (CSPs) is the notion of a relational clone, which is the set of all relations expressible using primitive positive formulas over a particular set of base relations. Post'
Bulatov, AA, Dyer, M, Jerrum, M, Goldberg, LA, McQuillan, C, Bulaov, AA, Bulatov, A   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Shape theory and mathematical design of a general geometric kernel through regular stratified objects

, 2000
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This dissertation focuses on the mathematical design of a unified shape kernel for geometric computing, with possible applications to computer aided design (
Gomes, Abel Joao Padrao
core  

Linear kernel for planar connected dominating set [PDF]

, 2009
We provide polynomial time data reduction rules for Connected Dominating Set in planar graphs and analyze these to obtain a linear kernel for the planar Connected Dominating Set problem.
Lokshtanov, Daniel, Lokshtanov, D., Mnich, M., Saurabh, S., Daniel Lokshtanov, Mnich, Matthias, Mnich, M Matthias, Matthias Mnich, Saurabh, S, Saket Saurabh, Saurabh, Saket   +10 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Set Covering Machine

, 2002
We extend the classical algorithms of Valiant and Haussler for learning compact conjunctions and disjunctions of Boolean attributes to allow features that are constructed from the data and to allow a trade-off between accuracy and complexity.
Marchand, Mario, Shawe-Taylor, J., Mario Marchand, John Shawe-Taylor   +3 more
core  

International Journal of Mathematical Combinatorics, Vol.4A [PDF]

, 2010
The International J.Mathematical Combinatorics (ISSN 1937-1055) is a fully refereed international journal, sponsored by the MADIS of Chinese Academy of Sciences and published in USA quarterly comprising 460 pages approx.
Mao, Linfan (Editor-in-Chief)
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Tilings and other combinatorial results

, 2018
In this dissertation we treat three tiling problems and three problems in combinatorial geometry, extremal graph theory and sparse Ramsey theory. We first consider tilings of $\mathbb{Z}^n$.

core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source