Results 81 to 90 of about 21,635,005 (257)

Missing Links: Politics and the Misrecognition of the Sweden Democrats

open access: yesScandinavian-Canadian Studies, 2018
: This article critiques prevailing approaches to the study of the Sweden Democrats political party. It argues that political agendas motivate academic and journalistic commentators to adopt a limited definition of the
Benjamin R. Teitelbaum
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Sex differences in fiber connection from the striatum to subcortical and cortical regions

open access: yesFrontiers in Computational Neuroscience, 2016
The striatum is an important subcortical structure with extensive connections to other regions of the brain. These connections are believed to play important roles in behaviors such as reward-related processes and impulse control, which show significant ...
XUEMEI LEI   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Sàl:Third Performance at Mitchell theatre, Glasgow, Celtic Connections

open access: yes, 2019
Performance at Mitchell theatre, Glasgow, Celtic Connections.
Dalziel, Matthew   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Understanding the political connections of Portuguese companies through their board members [PDF]

open access: yesEuropean Journal of Management Studies
Purpose – This study aims to analyse the political connections of Portuguese companies through the members of the board of directors, exploring how these connections influence, in particular, the composition and characteristics of the boards.
Paulo Ferreira   +2 more
doaj   +1 more source

Other title: Connections, 2018

open access: yes, 2018
Annual cumulation of 2018 issuesGovernor Sam Brownback Appoints KDHE Chief Medical Officer Use FoodSafetyKansas.org To Report Food Complaints NACCHO Announces Funding Opportunity For Rural LHDS Focused On SDOH January 2018 Is Kansas Radon Action Month ...
Bureau of Community Health Systems Kansas. Department of Health and Environment
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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