Results 101 to 110 of about 339,498 (258)

Two HSCT Mach 1.7 low sonic boom designs [PDF]

, 1992
The objective of this study was to provide low sonic boom concepts, geometry, and analysis to support wind tunnel model designs. Within guidelines provided by NASA, two High Speed Civil Transport (HSCT) configurations were defined with reduced sonic boom
Haglund, George T., Ogg, Steven S.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analytical and experimental investigation of stator endwall countouring in a small axial-flow turbine [PDF]

An experimental and analytical investigation was conducted to determine the effect of stator endwall contouring on turbine stage performance. In this investigation three stator configurations were evaluated using a common rotor.
Boyle, R. J., Haas, J. E.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficient parameter estimation for the Poisson–Ailamujia distribution under ranked set and simple random sampling

Applied Mathematics in Science and Engineering
This study presents a comparative analysis of parameter estimation methods for the discrete Poisson–Ailamujia distribution, a model suitable for rare-event data that has received limited attention in the statistical literature, under both simple random ...
Tenzile Erbayram, Ibrahim Elbatal, Yunus Akdoğan, Ahmed Z. Afify   +3 more
doaj   +1 more source

Transparent conducting oxides for electro-optical plasmonic modulators

Nanophotonics, 2015
The ongoing quest for ultra-compact optical devices has reached a bottleneck due to the diffraction limit in conventional photonics. New approaches that provide subwavelength optical elements, and therefore lead to miniaturization of the ...
Babicheva Viktoriia E., Boltasseva Alexandra, Lavrinenko Andrei V.   +2 more
doaj   +1 more source

Design and Analysis of the Onsala 4mm Receiver and other Antenna Configurations for Millimetre Wave Astronomy

, 2016
This thesis outlines several different topics associated with the design and analysis of millimetre and submillimetre systems. A major topic is the design, analysis and verification of a 4 mm receiver for the 20 m telescope at Onsala Space Observatory, Onsala, Sweden.
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source