Results 81 to 90 of about 21,407,987 (264)

Nested Maximin Latin Hypercube Designs [PDF]

In the field of design of computer experiments (DoCE), Latin hypercube designs are frequently used for the approximation and optimization of black-boxes.
Rennen, G., Dam, E.R. van, Husslage, B.G.M., Hertog, D. den   +3 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Optimal Discrimination Designs for Exponential Regression Models [PDF]

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw (1995) or Gibaldi and Perrier (1982). We discuss different approaches for
Dette, Holger, Pepelyshev, Andrey, Biedermann, Stefanie   +2 more
core  

Quantum illumination networks

Communications Physics
Quantum illumination is an entanglement-based target detection protocol that provides quantum advantages despite entanglement-breaking noise. However, the advantage of traditional quantum illumination protocols is limited to impractical scenarios with ...
Xiaobin Zhao, Zheshen Zhang, Quntao Zhuang   +2 more
doaj   +1 more source

Comprehensive review of serpentine flow fields for effective thermal management of proton exchange membrane fuel cell

Heliyon
Besides the fact that the Proton Exchange Membrane Fuel Cells (PEMFCs) have become the industrial norm of today, the thermal management in PEMFCs is still challenging.
Muhammad Ahmed, Xiong Shusheng
doaj   +1 more source

Behavior of Evacuees on Upper‐Level Walkways After Building Evacuation due to Fire: Design Implications From a Virtual Reality Study on Spatial Configuration, Density, and Influence of Other Evacuees' Route Choice

JAPAN ARCHITECTURAL REVIEW
ABSTRACT In the central districts of Japanese cities, numerous large‐scale buildings are connected to upper‐level walkways, which serve as everyday circulation routes. However, the behavior of evacuees on these walkways during fires remains poorly understood.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Combinatorial Designs with Two Singular Values I. Uniform Multiplicative Designs [PDF]

In this and a sequel paper [10] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize 2-(v, k, É) designs, and include partial geometric designs and uniform multiplicative designs.Here we study the latter,
Spence, E., Dam, E.R. van
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source