Results 81 to 90 of about 339,498 (258)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Communications PhysicsQuantum illumination is an entanglement-based target detection protocol that provides quantum advantages despite entanglement-breaking noise. However, the advantage of traditional quantum illumination protocols is limited to impractical scenarios with ...
Xiaobin Zhao +2 more
doaj +1 more source
HeliyonBesides the fact that the Proton Exchange Membrane Fuel Cells (PEMFCs) have become the industrial norm of today, the thermal management in PEMFCs is still challenging.
Muhammad Ahmed, Xiong Shusheng
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Effects of fuselage forebody geometry on low-speed lateral-directional characteristics of twin-tail fighter model at high angles of attack [PDF]
Low-speed, static wind-tunnel tests were conducted to explore the effects of fighter fuselage forebody geometry on lateral-directional characteristics at high angles of attack and to provide data for general design procedures.
Carr, P. C., Gilbert, W. P.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Applied Mechanics and Engineering, 2017 The performance of buckling load of tubular structures under quasi-static axial loading is quite appreciable, numerous tubes of various cross-section have been extensively investigated and corrugated sections have been designed to further improve the ...
Mohammad Reyaz Ur Rahim +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Ion source design for industrial applications [PDF]
The design of broad-beam industrial ion sources is described. The approach used emphasizes refractory metal cathodes and permanent-magnet multipole discharge chambers.
Kaufman, H. R., Robinson, R. S.
core +1 more source