Results 71 to 80 of about 48,533 (272)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FADO: Floorplan-Aware Directive Optimization for High-Level Synthesis Designs on Multi-Die FPGAs
, 2023 Multi-die FPGAs are widely adopted to deploy large-scale hardware accelerators. Two factors impede the performance optimization of high-level synthesis (HLS) designs implemented on multi-die FPGAs. On the one hand, the long net delay due to nets crossing
Xie, Zhiyao +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Social Designs: Tank Irrigation Technology and Agrarian Transformation in Karnataka, South India
, 2003 Tank Irrigation of South India is largely considered “traditional”, “alternative”, or “appropriate” form of irrigation in the current academic and policy circles.
Shah, E.
core
A Novel Airframe Design Methodology For Silent Aircraft [PDF]
, 2008 The impact of noise on civil aviation is not just a localised airport problem, but a global concern, due to the ever-increasing demands for passenger travel.
Mistry, Sunil
core
Forced Choice Assessment of Work Related Maladaptive Personality Traits: Preliminary Evidence from an Application of Thurstonian Item Response Modeling [PDF]
, 2016 This article describes an investigation of whether Thurstonian item response modeling is a viable method for assessment of maladaptive traits. Forced-choice responses from 420 working adults to a broad-range personality inventory assessing six ...
Cooper, Andrew J. +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A Computational Fluid Dynamics Study in a PEM Fuel Cell with Different Flow Fields
International Journal of Electrochemical Science, 2020 In this paper, a computational fluid dynamics (CFD) study in a proton exchange membrane fuel cell model with different flow field designs is presented.
C.E. Hernández-Herrera +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source