Results 61 to 70 of about 1,856,164 (287)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Carbon nanotubes for epoxy Nanocomposites: a review on recent developments [PDF]

open access: yes, 2012
Carbon nanotubes (CNTs) are one of the strongest and stiffest engineering fibres. Due to their unique combination of chemical and physical properties at an incredibly small size, they possess great potential to be used as nanofillers for many structural ...
Inam, Fawad, Luhyna, Nataliia
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Quantifying Changes in Creativity: Findings from an Engineering Course on the Design of Complex and Origami Structures [PDF]

open access: yes, 2018
Engineering educators have increasingly sought strategies for integrating the arts into their curricula. The primary objective of this integration varies, but one common objective is to improve students’ creative thinking skills. In this paper, we sought
Anwar, Sohel   +5 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Collaborative meta-profile development to harmonise mechanical engineering education in Africa

open access: yesTuning Journal for Higher Education, 2014
This paper describes the contribution of the Tuning Methodology toward harmonisation of undergraduate mechanical engineering programmes in Africa. This methodology is an interactive process in which academics develop high quality curricula and learning ...
S. M. Sackey   +11 more
doaj   +1 more source

Statistical multivariate monitoring of rolling bearings working under varying operational conditions

open access: yesIET Science, Measurement & Technology, 2021
In recent years, statistical data‐driven approaches have been developed for health monitoring of rolling bearings working under variable operational conditions.
Baoxiang Wang, Hongxia Pan
doaj   +1 more source

Measurement of cavitation in a sliding bearing using digital holography [PDF]

open access: yes, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014)   +3 more
core  

Systematic innovation and the underlying principles behind TRIZ and TOC [PDF]

open access: yes, 2003
Innovative developments in the design of product and manufacturing systems are often marked by simplicity, at least in retrospect, that has previously been shrouded by restrictive mental models or limited knowledge transfer. These innovative developments
D. Mann   +5 more
core   +2 more sources

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