Results 71 to 80 of about 1,849,736 (267)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Measurement of cavitation in a sliding bearing using digital holography [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +3 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Mechanical Engineering: Medium-Sized Companies with Highest Savings Potential [PDF]
The German mechanical engineering industry, dominated by medium-sized companies, is greatly successful - both on the domestic and on the international market.
Alexander S. Kritikos +1 more
core
Raising sector skills levels : how responsive is local training supply? [PDF]
, 2005 This UK study examines the extent and nature of any mismatches between the training requirements of employers and the local provision of vocational education and training (VET).
Mason, Geoff +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanics+Mechanical Engineering: Algorithm of Intensive Innovational Development
Механика машин, механизмов и материалов, 2007 The base directions of realization of the State program of country innovational development for 2006—2010 years in the field of mechanical engineering, which are coordinated and carried out within the framework of the State complex goal-oriented ...
V.I. Semashko, M.S. Vysotsky
doaj
A CASE STUDY IN PROJECT BASED LEARNING USING FLOW VISUALISATION [PDF]
Journal of Engineering Science and Technology, 2007 Engineering Design modules, usually introduced in the first and second year’s undergraduate Mechanical Engineering courses, present a unique platform to practice the Project Based Learning (PBL).
MUSHTAK AL-ATABI, S.B. CHIN
doaj
Recent research and development of structural control in Japan
Japan Architectural Review, 2019 In Japan, structural control is widely recognized as a fundamental technology for exceeding the performance limitations of conventional earthquake/wind‐resistant buildings.
Yoshiki Ikeda +3 more
doaj +1 more source