Results 31 to 40 of about 236,240 (236)

Hybrid finite difference/finite element immersed boundary method [PDF]

, 2017
The immersed boundary method is an approach to fluid-structure interaction that uses a Lagrangian description of the structural deformations, stresses, and forces along with an Eulerian description of the momentum, viscosity, and incompressibility of ...
Griffith, Boyce E., Luo, Xiaoyu
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A numerical stabilization framework for viscoelastic fluid flow using the finite volume method on general unstructured meshes

, 2017
A robust finite volume method for viscoelastic flow analysis on general unstructured meshes is developed. It is built upon a general-purpose stabilization framework for high Weissenberg number flows.
Bothe, Dieter, Kunkelmann, Christian, Marschall, Holger, Niethammer, Matthias   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysis of Meshfree Galerkin Methods Based on Moving Least Squares and Local Maximum-Entropy Approximation Schemes

Mathematics
Over the last two decades, meshfree Galerkin methods have become increasingly popular in solid and fluid mechanics applications. A variety of these methods have been developed, each incorporating unique meshfree approximation schemes to enhance their ...
Hongtao Yang, Hao Wang, Bo Li
doaj   +1 more source

Stochastic Eulerian Lagrangian Methods for Fluid-Structure Interactions with Thermal Fluctuations

, 2010
We present approaches for the study of fluid-structure interactions subject to thermal fluctuations. A mixed mechanical description is utilized combining Eulerian and Lagrangian reference frames.
Alberts, Arienti, Armstrong, Atzberger, Atzberger, Banchio, Bedeaux, Bodard, Brady, Braescu, Chen, Da Prato, Danuser, De Fabritiis, Doi, Donev, Dowell, Eijkel, Ermak, Fisher, Fung, G Larson, Garcia, Gardiner, Gelfand, Givelberg, Gotter, Gottlieb, Griffith, Hauge, Hills, Kim, Kloeden, Kramer, Landau, Lebedev, Lieb, Lim, Mazur, Mezei, Miller, Mittal, Moffitt, Oksendal, Paul J. Atzberger, Peskin, Peskin, Purcell, Reichert, Reichl, Rotne, Saintillan, Squires, Strang, Strang, Strikwerda, Trefethen, Tuckerman, Valentine, Wang, Watari, Watson, Yamakawa, Zohdi   +63 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Discussions on Driven Cavity Flow

, 2009
The widely studied benchmark problem, 2-D driven cavity flow problem is discussed in details in terms of physical and mathematical and also numerical aspects. A very brief literature survey on studies on the driven cavity flow is given.
Abouhamza, Albensoeder, Albensoeder, Auteri, Aydin, Barragy, Batchelor, Benjamin, Burggraf, Cazemier, Dennis, Ding, Drazin, Erturk, Erturk, Erturk, Erturk, Fletcher, Fornberg, Fornberg, Fortin, Gervais, Ghia, Goyon, Haddad, Kim, Koseff, Koseff, Koseff, Liao, Liffman, Peng, Peregrine, Poliashenko, Prasad, Ramanan, Sahin, Schlichting, Schreiber, Shankar, Smith, Son, Tannehill, Tiesinga, Tuann, Wan, Weinan   +46 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source