Results 41 to 50 of about 14,885 (212)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Chemical Engineering Journal AdvancesArtificial intelligence (AI) is revolutionizing fluid mechanics as it provides revolutionary accuracy with complex, turbulent flows that can be modeled, speed up the simulation of fluid dynamics, and gain new findings from nonconventional data analysis ...
Zahoor Shah +8 more
doaj +1 more source
Finite Element Method Application in Areal Rainfall Estimation Case Study; Mashhad Plain Basin
مجله آب و خاک, 2016 Introduction: The hydrological models are very important tools for planning and management of water resources. These models can be used for identifying basin and nature problems and choosing various managements.
M. Irani, F. Khamchinmoghadam
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Machine Learning Reshaping Computational Fluid Dynamics: A Paradigm Shift in Accuracy and Speed
FluidsAccurate and efficient CFD simulations are essential for a wide range of engineering and scientific applications, from resilient structural design to environmental analysis.
Aly Mousaad Aly
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Advances in Unsteady Dynamics of Secondary Flow in 90° Pipe Bends [PDF]
长江科学院院报[Objective] The unsteady motion of secondary flow, namely Dean vortices, in bent pipes can induce thermal fatigue and mechanical fatigue, posing a serious threat to the safe operation of industrial piping systems.
WANG Zhi-xin, HAN Song-lin, JIANG Zhi-bing
doaj +1 more source