Results 61 to 70 of about 15,052 (259)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finite Element Method Application in Areal Rainfall Estimation Case Study; Mashhad Plain Basin
مجله آب و خاک, 2016 Introduction: The hydrological models are very important tools for planning and management of water resources. These models can be used for identifying basin and nature problems and choosing various managements.
M. Irani, F. Khamchinmoghadam
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Conditional and unconditional nonlinear stability in fluid dynamics [PDF]
, 2002 In this thesis we examine some of the interesting aspects of stability for some convection problems. Specifically, the first part of the thesis deals with the Bénard problem for various Non-Newtonian fluids, whereas the second part develops a stability ...
Budu, P., Budu, Paula
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Simulations of Compressible, Diffusive, Reactive Flows with Detailed Chemistry Using a High-Order Hybrid WENO-CD Scheme [PDF]
, 2012 A hybrid weighted essentially non-oscillatory (WENO)/centered-difference (CD) numerical method, with low numerical dissipation, high-order shock-capturing, and structured adaptive mesh refinement (SAMR), has been developed for the direct numerical ...
Ziegler, John Lewis (Jack)
core +1 more source
Chemical Engineering Journal AdvancesArtificial intelligence (AI) is revolutionizing fluid mechanics as it provides revolutionary accuracy with complex, turbulent flows that can be modeled, speed up the simulation of fluid dynamics, and gain new findings from nonconventional data analysis ...
Zahoor Shah +8 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2010 The research unit FOR 493 tackles the challenging task of fluid-structure interaction (FSI). On the one hand, the objective is to provide reliable experimental reference data for all groups which are developing numerical methodologies to predict such ...
Lienhart, Hermann +3 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Radial basis function based meshless methods for fluid flow problems
, 2006 This thesis is concerned with the development of meshless methods using radial basis functions for solving fluid flow problems. The advantage of meshless methods over traditional mesh-based methods is that they make use of a scattered set of collocation ...
Chinchapatnam, Phani P. +1 more
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