Results 81 to 90 of about 15,052 (259)

The Influence of the Protrusion Inclination Angle on the Formability of Hollow Joint in the Tube Hydroforming Process

Journal of Machine Engineering
Hollow joints formed through the tube hydroforming process offer superior advantages over traditional forming methods such as casting, welding, sheet metal bending, and cutting.
Nguyen Dac Trung, Vu Duc Quang
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Deep learning with fourier features for regressive flow field reconstruction from sparse sensor measurements

Scientific Reports
Many applications in computational and experimental fluid mechanics require effective methods for reconstructing the flow fields from limited sensor data.
Phong C. H. Nguyen, Joseph B. Choi, Quang-Trung Luu   +2 more
doaj   +1 more source

Dynamical and Computational Analysis of Fractional Korteweg–de Vries-Burgers and Sawada–Kotera Equations in Terms of Caputo Fractional Derivative

Fractal and Fractional
This work examines the fractional Sawada–Kotera and Korteweg–de Vries (KdV)–Burgers equations, which are essential models of nonlinear wave phenomena in many scientific domains.
N. S. Alharthi
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Stability and wave motion problems in continuous media with second sound [PDF]

, 2009
In this thesis we investigate thermal convection and wave motion in models of second sound such as the Cattaneo model, Green and Laws model, Batra model, and Green and Naghdi model. For the Green and Laws and Batra models we also investigate questions of
Jaisaardsuetrong, Jiratchaya
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Numerical modelling of viscous turbomachinery flows with a pressure correction method [PDF]

, 1992
A fully elliptic computational method for the analysis of steady viscous flow in high speed subsonic centrifugal compressor impellers with tip leakage, is presented.
Tourlidakis, A.
core