Results 41 to 50 of about 1,100,119 (264)

Methodological Aspects of Pedagogy’s Two-Discipline Location

open access: yesPrzegląd Badań Edukacyjnych, 2020
The area of pedagogy research penetration is situated in the disciplines of social sciences and humanities. The answer to the question what methodological consequences this brings to the practice of pedagogy favours the broadening of the ethodological ...
Danuta Urbaniak - Zając
doaj   +1 more source

A network to enhance the contributions from the social sciences and humanities to IPBES

open access: yesEcosystems and People, 2022
IPBES requires enhanced contributions from the social sciences and humanities in order to meet its mandate and influence policy. However, achieving this has so far proved challenging, notably in the form of a shortage in nominations of experts from these
Håkon B. Stokland   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Exploring how patients respond to GP recommendations for mental health treatment: an analysis of communication in primary care consultations

open access: yesBJGP Open, 2019
Background: Patient take-up and adherence to antidepressants and talking therapy is low. However, little is known about how GPs recommend these treatments and whether patients accept them.
Joseph Ford   +3 more
doaj   +1 more source

The impact of economics on the other social sciences

open access: yesTheoria, Beograd, 2017
In the paper, we thoroughly consider the dominant position of economics within the social sciences. We begin with the presentation of the relative isolation of economics and results of citation research of selected journals in Serbia and Russia.
Milos Krstic, Bojan Krstic
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Examining the Pattern of Impossibility of Islamic Theory of Sociology and Social Sciences in Iran [PDF]

open access: yesاسلام و مطالعات اجتماعی, 2017
The internal structure of the social sciences, the social contexts and implications that allowed to emerge in it, are issues that have attracted attention of the many in recent decades.
Seyed Mahdi Etemadifard   +1 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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