Results 71 to 80 of about 1,100,119 (264)

Otherness measuring scale: design and validation for social sciences

BMC Psychology
AbstractThis paper is the result of a scale validation process, applicable to social science research, which allows the constructs of otherness and coexistence and their relationship to be trasnformed into measurable, systematized variables. In turn, this scale is the product of a research project whose main objectives were (i) to demonstrate the ...
Cirit Mateus, Daladier Jabba, Ana María Erazo, Ignácio Aguaded, Rodrigo Campis, Alexander Parody-Muñoz   +5 more
openaire   +4 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effectiveness of behavioral intervention programs for preventing and managing diabetes in adults: a systematic review of evidence

BMC Public Health
Introduction Diabetes is a growing global health issue that can have serious consequences. As the value of behavioral intervention programs for preventing and managing this disease in adults becomes more evident, this study aimed to assess the ...
Adeel Aslam, Muhammad Daoud Butt, Iqra Javaid, Tooba Malik, Zeenia Gull, Ayesha Mahmood, Atika Afzal, Aqsa Adnan, Siew Chin Ong   +8 more
doaj   +1 more source

Are Single-Pilot Operations An Advantage Or A Disadvantage?

International Journal of Aviation, Aeronautics, and Aerospace
This study aims to investigate the potential benefits and drawbacks of Single-Pilot Operations (SPO) and to provide actionable insights for commercial airlines.
Ezgi Berte ERME
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Pre-Service Social Sciences Teachers’ Perspectives of their Teacher Professional Identity in a South African University within the Context of Curriculum Integration

African Journal of Inter-Multidisciplinary Studies
The purpose of this study is to investigate the perspectives of pre-service teachers regarding their identity as social sciences teachers. The aim is to summarise their subject and topic preferences within the social sciences curriculum and to propose ...
Tiani Wepener, Raymond Nkwenti Fru, Alan Felix, Mlamuli Tabhu   +3 more
doaj   +1 more source

An introduction to the Islamic foundation of research methodology [PDF]

فصلنامه نوآوری‌های آموزشی, 2007
The Islamic ontological and epistemological foundation is not in accordance with methodological segregation of natural sciences and social sciences on one hand and on the other hand does not accept the dominance of natural sciences methodology over ...
Jamileh Alam-ol-hoda
doaj