Results 181 to 190 of about 3,661,970 (379)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Voluntary information and price sharing database - a scoping review of the pricing and procurement landscape across eight Commonwealth Member States. [PDF]

J Pharm Policy Pract
Kebirungi B, Ocran P, Kamere N, Mabote LK, Osi N, Joshi-von Heyden M, Gilmour E, Mghamba J, Robinson L, Babar ZU, Rosado H, Rutter V.   +11 more
europepmc   +1 more source

An epitome of the natural history of the insects of China: : comprising figures and descriptions of upwards of one hundred new, singular, and beautiful species; together with some that are of importance in medicine, domestic economy, &c. The figures are accurately drawn, engraved and coloured, from specimens of the insects; the descriptions are arranged according to the system of the Linnaeus; with references to the writings of Fabricius, and other systematic authors

E. Donovan
openalex   +2 more sources

Taking Systems Medicine to Heart.

Circulation Research, 2018
Kalliopi Trachana, R. Bargaje, Gwênlyn Glusman, N. Price, Sui Huang, L. Hood   +5 more
semanticscholar   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Challenges and opportunities of complexity theory in health care systems. [PDF]

J Taibah Univ Med Sci
A'aqoulah A, El-Metwally AA, Al Khateeb B, Alammari D, Alshahrani A, Aldubikhi A, Alsulami A, Fatani F, Innab N.   +8 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

The Prognostic Role of Pitt Bacteremia Score in Patients With Nonbacteremic <i>Klebsiella pneumoniae</i> Infections. [PDF]

Can J Infect Dis Med Microbiol
Chang JM, Lin KH, Lai CH, Tsai IT, Hsu YC.   +4 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Predictive techniques in medical imaging: opportunities, limitations, and ethical-economic challenges. [PDF]

NPJ Digit Med
Saba L, d'Aloja E.
europepmc   +1 more source