Results 231 to 240 of about 171,852,411 (303)

From Pieces to Processes: Teaching Health Care Process Optimization and Quality Improvement Through a Building Brick Simulation. [PDF]

MedEdPORTAL
Vredeveld JL, Burke D, Maben-Feaster RE, Frederick TS, Brenner MJ, Ruff AL.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Electronic Clinical Quality Measures of Antibiotic Use in Hospitalized Adults With Uncomplicated Community-Acquired Pneumonia. [PDF]

Clin Infect Dis
White AT, Bidwell Goetz M, Jones M, Neuhauser MM, Ciarkowski C, Ratz D, Gupta A, Petty LA, Gandhi TN, Zhang M, Kent B, Wu C, Horowitz JK, Flanders SA, Srinivasan A, Vaughn VM.   +15 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The status, or conspicuous absence, of regulation of proprietary or locally manufactured African traditional medicines in South Africa: a constitutional injustice. [PDF]

Front Public Health
Gambo A, Gqaleni N, Lebina L.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Implications of the new US AI framework in medicine. [PDF]

Commun Med (Lond)
Armoundas AA.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Growing pains: adult subspecialist perspectives on improving transition from paediatric to adult care for youth with complex health conditions. [PDF]

BMJ Open Qual
Malecki S, Nwebube C, Orkin J, Halperin I, Khan N, John T, Katzberg H, Steiman A, Matta R, Abdelhalim T, Andrade DM, Bollegala N, Bush S, Ryan C, Colapinto K, Dimaraki E, Faghfoury H, Fu J, Gakhal N, Gent K, Korenblum C, Lansang P, Lega IC, Lim-Fat MJ, Liu J, Miranda S, Mukerji G, Pagnoux C, Vandepoele E, Vinik O, Wentzel K, Yates D, Cohen E, Toulany A.   +33 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source