Results 241 to 250 of about 171,852,411 (303)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery. [PDF]

open access: yesTrends Biotechnol
Gao Q   +6 more
europepmc   +1 more source

World Kidney Day 2026 in Africa: bridging environmental sustainability with the realities of kidney care. [PDF]

open access: yesRen Fail
Nzana VB   +6 more
europepmc   +1 more source

Trends in Thrombolysis in Stroke (2015-2024). [PDF]

open access: yesAcad Emerg Med
Wright DS   +6 more
europepmc   +1 more source

Adapting and implementing health systems guidelines: learning lessons from countries. [PDF]

open access: yesHealth Res Policy Syst
Zeitouny S   +7 more
europepmc   +1 more source

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