Results 61 to 70 of about 4,362,278 (303)

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

open access: yesFEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause   +2 more
wiley   +1 more source

Changes in antimicrobial prescribing behavior after the introduction of the antimicrobial stewardship program: A pre- and post-intervention survey

open access: yesInfectious Disease Reports, 2017
The introduction of an antimicrobial stewardship (AMS) program is associated with a change in antimicrobial prescribing behavior. A proposed mechanism for this change is by impacting the prescribing etiquette described in qualitative studies.
Ruchir Chavada   +3 more
doaj   +1 more source

Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study

open access: yesBMC Complementary Medicine and Therapies, 2021
Background Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties of Poly (caprolactone)/ Poly (vinyl
Mohammad Saeid Salami   +5 more
doaj   +1 more source

Multimedia-based Medicinal Plants Sustainability Management System [PDF]

open access: yesIJCSI International Journal of Computer Science Issues, Vol. 8, Issue 5, No 3, September 2011; ISSN (Online): 1694-0814, 2011
Medicinal plants are increasingly recognized worldwide as an alternative source of efficacious and inexpensive medications to synthetic chemo-therapeutic compound. Rapid declining wild stocks of medicinal plants accompanied by adulteration and species substitutions reduce their efficacy, quality and safety.
arxiv  

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

open access: yesFEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine   +3 more
wiley   +1 more source

Screening and detection of heterogenous vancomycin intermediate Staphylococcus aureus in Hospital Kuala Lumpur Malaysia, using the glycopeptide resistance detection etest and population analysis profiling

open access: yesInfectious Disease Reports, 2012
In a 3-month study done in Hospital Kuala Lumpur (HKL), 7 out of 320 methicillin resistant Staphylococcus aureus isolates were confirmed as heterogeneous vancomycin intermediate S.
Siti Roszilawati Ramli   +3 more
doaj   +1 more source

AI and Medicine [PDF]

open access: yesarXiv, 2019
Which part of medicine, if any, can and should be entrusted to AI, now or at some moment in the future? That both medicine and AI will continue to change goes without saying.
arxiv  

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Repeated Dientamoeba fragilis infections: a case report of two families from Sydney, Australia

open access: yesInfectious Disease Reports, 2009
We report cases of two unrelated families who both presented with recurrent Dienta-moeba fragilis infections. Subsequent antimicrobial therapy resulted in the clearance of D.
Damien Stark   +4 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy