Results 81 to 90 of about 2,020,687 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Breathable medicine : pulmonary mode of drug delivery

, 2015
Pharmaceutically active compounds require different modes of drug delivery systems to accomplish therapeutic activity without loss of its activity and lead to exhibit no adverse effects.
Tay, Samuel Sam Wah, Sundarrajan, Subramanian, Kumar, Srinivasan Dinesh, Sridhar, Radhakrishnan, Gandhimathi, Chinnasamy, Venugopal, Jayarama Reddy, Ramakrishna, Seeram   +6 more
core   +1 more source

Anti-inflammatory, immuno-modulatory, and anti-proliferative effects of 5-mer Oligogalacturonides (OG DP5) from citrus pectin on different types of human cells. Perspectives for treatment of dermal diseases such as atopic dermatitis and psoriasis

Phytomedicine Plus
Background: Oligogalacturonides (OG) are natural plant cell wall pectin-derived products with different degrees of polymerisation (DP) and methylation (M) (see Yu et al. 2022).
Lény Teyssier, Lamotte Olivier, Bonnin Estelle, Crépeau Marie-Jeanne, Cussac Didier, Jeandroz Sylvain, Wendehenne David, Pelloux Jérôme, Jean-Louis Connat   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Azadirachta indica fruit juice clears malaria parasites and replenishes blood levels in Plasmodium berghei-infected mice

Phytomedicine Plus
Abstact: Background: One of the major pathogenesis of malaria parasite infection is the invasion and destruction of the Red Blood Cells, which requires the joint administration of antimalarial and most times essential nutrients for effective treatment ...
Ikechuku Okorie Igwenyi, Chinemelum Adaora Onodugo, Patrick Maduabuchi Aja, Sunday Oge Elom, Joshua Nonso Awoke, Osarieme Sandra Ibhadode, Anayo Joseph Uraku, Nzubechukwu Edwin, Ajuka Nwogo Obasi, Ebuka Elijah David, Ijeoma Precious Igwenyi, Patience Nkemjika Ogbu, Chinedu Egwu, Ayomide Victor Atoki   +13 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cytotoxic and apoptotic effect of Vernonia amygdalina Delile. fractions against Hs578t triple-negative breast cancer cell lines

Phytomedicine Plus
Background: Triple-negative breast cancer (TNBC) is a type of breast cancer whose treatment is significantly more complicated than that for other forms of breast cancer.
Denny Satria, Poppy Anjelisa Zaitun Hasibuan, Mahatir Muhammad, Syukur Berkat Waruwu, Rohmad Yudi Utomo, Salar Hafez Ghoran   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Drugs Affecting 5-HT Systems

, 2013
Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core  

Creating Safe Connections: A Co-Designed E-Learning Module to Advance Equity and Social Accountability in Preventative Primary Care

Advances in Medical Education and Practice
Ambreen Sayani,1,2 Zeenat Ladak,1,3 Jackie Manthorne,4 Erika Nicholson,5 Gary C Bloch,6,7 Janet Parsons,2 Stephen W Hwang,6 Bikila Amenu,8 Howard Freedman,8 Tara Jeji,8 Angus Pratt,8 Vinesha Ramasamy,8 Jean-Claude Camus,8 C Nadine Wathen,9 Jennifer CD ...
Sayani A, Ladak Z, Manthorne J, Nicholson E, Bloch GC, Parsons J, Hwang SW, Amenu B, Freedman H, Jeji T, Pratt A, Ramasamy V, Camus JC, Wathen CN, MacGregor JCD, Dilkes D, Lofters A   +16 more
doaj