Results 81 to 90 of about 46,631 (216)

Photo-physical characterizations and evaluation of in-vitro antioxidant, anti-inflammatory and antidiabetic potentials of green synthesized ackee (Blighia sapida) selenium nano-particles

BMC Complementary Medicine and Therapies
Background Green synthesized nanoparticles have recently gained significant medicinal applications and oftentimes outperform their green sources. Selenium is of fundamental importance to human health, stemming from its distinctive physicochemical ...
Omodele Ibraheem, Olubukola Helen Oyeniran, Oluwatobiloba Moses Ogundipe, Eunice Oluwabukunmi Abe, Temitope Adenike Oyedepo, Kehinde Oluseun Sodeinde, Stephen Oluwaseyi Damola, Tosin Benjamin Adeola   +7 more
doaj   +1 more source

Systems medicine, an approach in a framework to guide development of preventative, diagnostic and treatment methods for Covid-19 and other complex or novel diseases

, 2020
The Covid-19 has plunged the world into a pandemic where there is no specific cure yet. Scientists around the world are researching and running trials to find highly effective prevention methods and cure. There are three major existing medical approaches which have developed systematic methods to diagnose ,prevent and treat diseases , the TCM, evidence
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo

BMC Complementary Medicine and Therapies
Background Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality.
Chuyi Yu, Haoyu Xing, Xiaguo Fu, Yingying Zhang, Xiufang Yan, Jianjia Feng, Zhouqin He, Li Ru, Chunlong Huang, Jianming Liang   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Self-stretching exercises with kinesio taping for management of chronic nonspecific neck pain in taxi drivers: A single-blind, randomized controlled trial

Complementary Therapies in Medicine
Objectives: Taxi drivers experience chronic neck pain owing to their posture while driving. The aim of this study was to investigate the effect of self-stretching exercises with kinesio taping on pain, stress, pressure pain threshold (PPT), disability ...
Jae-Jung Jeon, Sun-Hee Jeon, Keun-Jung Yang, Han Choi, Hwi-young Cho, Suk-Chan Hahm   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin

Chinese Medicine
Background Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in
Qian Zeng, Bin-bin Wen, Xin Liu, Yong-yu Luo, Zhen-gang Hu, Lei Huang, Xiao-hua Zhang, Xiao-ting Huang, Ting-ting Zhou, Xiao-xue Sang, Yu-yang Luo, Da-yan Xiong, Zi-qiang Luo, Wei Liu, Si-yuan Tang   +14 more
doaj   +1 more source

Acupuncture for the Treatment of Neuropsychiatric Symptoms in Parkinson's Disease: A Systematic Review and Meta-Analysis

Complementary Therapies in Medicine
Background: Neuropsychiatric symptoms (NPSs) of Parkinson's disease (PD) have received increasing attention, but effective treatment options remain limited.
Anxin Zhang, Zefeng Song, Anqi Di, Zelin Zhou, Liang Zheng, Lixing Zhuang   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source