Results 101 to 110 of about 3,865,257 (306)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Network pharmacology and experimental investigation of the protective effect of Shuxuetong injection against diabetic nephropathy and encephalopathy in db/db mice

Phytomedicine Plus
Objective: To investigate the protective effects and mechanism of Shuxuetong injection on diabetic nephropathy and encephalopathy in db/db mice by integrating animal experiments and network pharmacology.
Jia Liu, Yifei Geng, Yunfeng Pan, Xiao Sun, Shunliang Zheng, Zhiwei Zhang, Jisheng Huang, Yun Luo, Xiaobo Sun   +8 more
doaj   +1 more source

Stemming the Global Trade in Falsified and Substandard Medicines [PDF]

, 2013
Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and ...
Buckley, Gillian J., Gostin, Lawrence O., Kelley, Patrick W.   +2 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Ameliorative and protective effect of Bergenia ciliata (Haw.) Sternb. extract against acetaminophen-induced hepato-renal damage in rats

Phytomedicine Plus
Background: Bergenia ciliata (Haw.) Sternb. is a medicinal plant bestowed with antioxidative phytochemicals and has been traditionally associated with several medicinal and health-promoting properties and used in the management of diseases.Method: The ...
Makhmoor Ahmad Bhat, Rajinder Raina, Pawan Kumar Verma, Shilpa Sood, Zuhaib F. Bhat   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Review on the secondary metabolites, biological properties, and ethnomedicinal uses of the component species of the buheri wa afya formula used to treat COVID-19 in Tanzania

Phytomedicine Plus
Background: It has proven difficult to treat viral infections like SARS-CoV, MERS-CoV, and SARS-CoV-2 that cause severe respiratory disorders with the currently available medications.
John J. Makangara, Anthony M. Mshandete, Ernest R. Mbega, John R. Nyika, Frank Mbago, Edward G. Ndilanha, Raphael J. Nyika, Joseph J. Nyika   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genus Primula and its role in phytomedicine; a systematic review

Phytomedicine Plus
Background: Primula is one of the prevalent and complex genus of family Primulaceae. Plants of Genus Primula are used in traditional medicine for treating various ailments. These plants are mostly growing in soggy meadows to alpine slopes.
Fiaz Alam, Kinza Muhammad Din, Mehak Sarfraz, Atifa Qudoos, Shazia Malik   +4 more
doaj   +1 more source

National Academy of Medicine of Mexico position in favor of regulating the use of stem cells and human embryos for therapeutic or experimental purposes other than clinical protocols approved by the National Health System [PDF]

Gaceta Médica de México, 2023
Armando Mansilla, Julieta Rojo-Medina, María de Jesús Medina, Fermín Valenzuela-Gómez-Gallardo, Joaquín López-Bárcena, Fernando Meneses-González, Iván Velazco, Héctor Mayani, José Ignacio Santos-Preciado   +8 more
openaire   +1 more source